Glycine R Antibody [Unconjugated] - Pan Specific Summary
Peptide from the N-terminus region of the alpha 1 subunit of the rat Glycine Receptor
Specific for the ~48 kDa alpha 1 and alpha 2 subunits of the Glycine Receptor in Western blots of rat spinal cord, brain stem and cell extracts. Immunolabeling is blocked by preadsorption of antibody with the peptide immunogen. This antibody does not recognize other Glycine Receptor subunits.
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- Western Blot 1:1000 dilution
- Immunohistochemistry 1:1000 dilution
Packaging, Storage & Formulations
The lyophilized product is stable at ≤- 20° C for at least 1 year. After reconstitution the antibody should be aliquoted and stored at ≤ -20° C.
Lyophilized in 5 mM ammonium bicarbonate
This antibody should be reconstituted in 100 μL phosphate buffered saline (137 mM NaCl, 7.5 mM Na2HPO4, 2.7 mM KCl, 1.5 mM KH2PO4, pH 7.4) before use.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for Glycine R Antibody [Unconjugated] - Pan Specific
The rat glycine receptor (GlyR) chloride channel is a member of the nicotinic acetylcho-line receptor family of ligand-gated ion channels. Its glycine-mediated activation results in an influx of chlorine ions that hyperpolarize and desensitize neuronal postsynaptic membranes. The receptor’s multimeric makeup is unclear. It may be either a three or five subunit homo- or heteromultimer. To date, there are five rat GlyR subunit types. Four are 48-53 kDa alpha -type subunits, and one is a 58 kDa beta -type subunit. Alternate splicing exists for alpha 1 and alpha 2 subunit types. Alpha-type subunits may form homotrimers; however, their function may not be neurotransmission but rather non-synaptic cell-cell communication. Alpha1-beta multimers may be the principal synaptic GlyR in adults.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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