Geldanamycin

Product Image: Geldanamycin [NB110-81559] - Chemical structure of Geldanamycin (NB110-81559), a Geldanamycin. Molecular Formula: C29H40N2O9. Molecular Weight: 560.6 g/mol.

• Applications: Func, NULL

Geldanamycin Summary

• Description: Hsp90 inhibitor. Molecular Formula C29H40N2O9. Molecular Weight 560.6 g/mol.
• Specificity: Geldanamycin Compound

Applications/Dilutions

• Dilutions:
  • Adhesion Activation
  • Product Image
• Application Notes: Yellow solid. Slightly soluble in methanol, chloroform or DMSO (10 mg/mL); insoluble in water.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.

Background

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.