Geldanamycin produced by fermentation. >95% pure Slightly soluble in methanol, chloroform or DMSO (10mg/mL); insoluble in water. Yellow solid
Packaging, Storage & Formulations
Store at -20C. Avoid freeze-thaw cycles.
Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed
for 6 months from date of receipt.
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