Geldanamycin

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Product Details

Summary

Order Details

Geldanamycin Summary

Specificity
Geldanamycin Compound

Applications/Dilutions

Application Notes
Geldanamycin produced by fermentation. >95% pure Slightly soluble in methanol, chloroform or DMSO (10mg/mL); insoluble in water. Yellow solid

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.

Background

Geldanamycin is a benzoquinoid ansamycin produced by Streptomyces hygroscopicus. It binds specifically to heat shock protein HSP90 and downregulates target proteins including tyrosine kinases, steroid receptors, transcription factors and cell cycle regulatory kinases (1,2). It induces the inactivation, destabilization and eventual degradation of HIF-1

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.

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