FK506 Antibody (FK1) [FITC]

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Product Details

Summary
Reactivity NASpecies Glossary
Applications ELISA
Clone
FK1
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

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FK506 Antibody (FK1) [FITC] Summary

Immunogen
FK-506-BSA conjugate
Specificity
NB100-62571 detects FK-506, a macrolide with similar but more potent immunosuppressant activity than cyclosporine. It is a 23-membered lactone produced by the bacteria Streptomyces tsukubaensis. FK-506 inhibits signal transduction and interleukin-2 transcription in CD4+ T helper lymphocytes, and is mainly used after allogenic organ transplantation to reduce organ rejection. Side effects of FK-506 treatment include nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension.
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Purity
IgM purified
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Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000

Reactivity Notes

Reacts with Chemical.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
50 mM Tris/HCl, (pH 8.0) 150 mM NaCl
Preservative
0.05% Sodium Azide
Purity
IgM purified

Background

FK506 antigen is a novel macrolide with similar but more potent immunosuppressant activity than cyclosporine. FK506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant FK506 side effects are nephrotoxicity, neurotoxicity, diabetes mellitus and hypertension. Most of these side effects are more closely related to FK 506 blood levels than dosage; therefore therapeutic drug monitoring (TDM) of FK506 levels is a prerequisite for therapy. Whole blood is the matrix of choice for FK506 TDM. The whole blood target level range aimed for in clinical practice is between 3.0 and 20.0 ng/ml and depends on the patient's liver function, the type of organ transplanted and the time after transplantation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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