Mouse CTX-1 ELISA Kit (Colorimetric)

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Mouse CTX-1 ELISA Kit (Colorimetric) - Standard Curve Reference
ELISA: Mouse CTX-1 ELISA Kit (Colorimetric) [NBP2-69074] - Standard curve. Image from verified customer review.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-69074
    • Availability
      Product Discontinued

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Mouse CTX-1 ELISA Kit (Colorimetric) Summary

Specificity
This kit recognizes Mouse CTX1 in samples. No significant cross-reactivity or interference between Mouse CTX1 and analogues was observed.
Standard Curve Range
0.16 - 10 ng/mL
Sensitivity
0.10 ng/mL
Assay Type
Sandwich-ELISA
Inter-Assay
CV% < 4.41%
Intra-Assay
CV% < 4.7%
Spike Recovery
86-110%
Sample Volume
100 uL
Kit Type
ELISA Kit (Colorimetric)

Applications/Dilutions

Dilutions
  • ELISA
Reviewed Applications
Read 1 Review rated 5
using
NBP2-69074 in the following application:

Publications
Read Publications using
NBP2-69074 in the following applications:

Packaging, Storage & Formulations

Storage
Storage of components varies. See protocol for specific instructions.

Kit Components

Components
  1. Biotinylated Detection Ab Diluent
  2. Certificate of Analysis
  3. Concentrated Biotinylated Detection Ab (100×)
  4. Concentrated HRP Conjugate (100×)
  5. Concentrated Wash Buffer (25×)
  6. HRP Conjugate Diluent
  7. Micro ELISA Plate(Dismountable)
  8. Plate Sealer
  9. Product Description
  10. Reference Standard & Sample Diluent
  11. Reference Standard
  12. Stop Solution
  13. Substrate Reagent

Alternate Names for Mouse CTX-1 ELISA Kit (Colorimetric)

  • Collagen Type 1 C-Telopeptide
  • Cross Linked C-telopeptide of Type I Collagen
  • CTX
  • CTXI

Background

CTX-1, also referred to as either carboxy-terminal cross-linked telopeptide of type 1 collagen or C-terminal end of the telopeptide of type I collagen, is a marker of osteoporosis and bone resorption (1,2). CTX-1 is a common bone turnover marker (BTM) that can easily be measured in the plasma, serum, or urine (1-3). Bone turnover refers to the removal of old bones by resorption followed by generation of new bones (3). CTX-1 is released from intact collagen type 1 by cathepsin K cleavage and can be detected by an antibody against the eight amino acid sequence EKAHDGGR (2,4). Levels of CTX-1 show circadian rhythm variabilities altered by food intake, which makes timing of sample collection an important consideration and is typically done in a fasted state (1,3). Studies show that increased levels of CTX-1 along with bone-specific alkaline phosphatase (BSALP) is associated with increased risk for bone fractures and osteoporosis (3). The most common treatment for osteoporosis is bisphosphonates, which are classified as anti-resorptive drugs that slow the removal of bone (1,3). Another treatment is the Denosumab, a monoclonal antibody for receptor activator of NFkappaB ligand, which shows decreased levels of CTX-1 and other markers within the first 24-hours of treatment (1-3). Conversely, anabolic therapies add bone by focusing on the osteoclast and osteoblast populations. Romosozumab is one specific anabolic drug that showed quick decrease in CTX-1 levels following treatment (2,3).

References

1. Williams, C., & Sapra, A. (2020). Osteoporosis Markers. In StatPearls. StatPearls Publishing.

2. Szulc P. (2018). Bone turnover: Biology and assessment tools. Best Practice & Research. Clinical Endocrinology & Metabolism. https://doi.org/10.1016/j.beem.2018.05.003

3. Park, S. Y., Ahn, S. H., Yoo, J. I., Chung, Y. J., Jeon, Y. K., Yoon, B. H., Kim, H. Y., Lee, S. H., Lee, J., & Hong, S. (2019). Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment. Journal of Bone Metabolism. https://doi.org/10.11005/jbm.2019.26.4.213

4. Cremers, C., Garnero, P., Seibel, M. J. (2008). Chapter 87- Biochemical Markers of Bone Metabolism. Principles of Bone Biology (Third Edition). https://doi.org/10.1016/B978-0-12-373884-4.00020-3.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Publications for CTX-1 ELISA Kit (NBP2-69074)(6)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ELISA.


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Review for CTX-1 ELISA Kit (NBP2-69074) (1) 51

Average Rating: 5
(Based on 1 review)

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 CTX-1 NBP2-69074
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5
reviewed by:
Verified Customer
02/12/2022
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Summary

Sample Testedmouse serum
LotYZY7K9X92R

Comments

CommentsThe kit works excellent for the mouse serum.

Product General Protocols

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FAQs for CTX-1 ELISA Kit (NBP2-69074) (0)

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Additional CTX-1 Products

Array NBP2-69074

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