Mouse CTX-1 ELISA Kit (Colorimetric)


Mouse CTX-1 ELISA Kit (Colorimetric) - Standard Curve Reference
ELISA: Mouse CTX-1 ELISA Kit (Colorimetric) [NBP2-69074] - Standard curve. Image from verified customer review.

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Mouse CTX-1 ELISA Kit (Colorimetric) Summary

This kit recognizes Mouse CTX1 in samples. No significant cross-reactivity or interference between Mouse CTX1 and analogues was observed.
Standard Curve Range
0.16 - 10 ng/mL
0.10 ng/mL
Assay Type
CV% < 4.41%
CV% < 4.7%
Spike Recovery
Sample Volume
100 uL
Kit Type
ELISA Kit (Colorimetric)


Reviewed Applications
Read 1 Review rated 5
NBP2-69074 in the following application:

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NBP2-69074 in the following applications:

Packaging, Storage & Formulations

Storage of components varies. See protocol for specific instructions.

Kit Components

  1. Biotinylated Detection Ab Diluent
  2. Certificate of Analysis
  3. Concentrated Biotinylated Detection Ab (100×)
  4. Concentrated HRP Conjugate (100×)
  5. Concentrated Wash Buffer (25×)
  6. HRP Conjugate Diluent
  7. Micro ELISA Plate(Dismountable)
  8. Plate Sealer
  9. Product Description
  10. Reference Standard & Sample Diluent
  11. Reference Standard
  12. Stop Solution
  13. Substrate Reagent

Alternate Names for Mouse CTX-1 ELISA Kit (Colorimetric)

  • Collagen Type 1 C-Telopeptide
  • Cross Linked C-telopeptide of Type I Collagen
  • CTX
  • CTXI


CTX-1, also referred to as either carboxy-terminal cross-linked telopeptide of type 1 collagen or C-terminal end of the telopeptide of type I collagen, is a marker of osteoporosis and bone resorption (1,2). CTX-1 is a common bone turnover marker (BTM) that can easily be measured in the plasma, serum, or urine (1-3). Bone turnover refers to the removal of old bones by resorption followed by generation of new bones (3). CTX-1 is released from intact collagen type 1 by cathepsin K cleavage and can be detected by an antibody against the eight amino acid sequence EKAHDGGR (2,4). Levels of CTX-1 show circadian rhythm variabilities altered by food intake, which makes timing of sample collection an important consideration and is typically done in a fasted state (1,3). Studies show that increased levels of CTX-1 along with bone-specific alkaline phosphatase (BSALP) is associated with increased risk for bone fractures and osteoporosis (3). The most common treatment for osteoporosis is bisphosphonates, which are classified as anti-resorptive drugs that slow the removal of bone (1,3). Another treatment is the Denosumab, a monoclonal antibody for receptor activator of NFkappaB ligand, which shows decreased levels of CTX-1 and other markers within the first 24-hours of treatment (1-3). Conversely, anabolic therapies add bone by focusing on the osteoclast and osteoblast populations. Romosozumab is one specific anabolic drug that showed quick decrease in CTX-1 levels following treatment (2,3).


1. Williams, C., & Sapra, A. (2020). Osteoporosis Markers. In StatPearls. StatPearls Publishing.

2. Szulc P. (2018). Bone turnover: Biology and assessment tools. Best Practice & Research. Clinical Endocrinology & Metabolism.

3. Park, S. Y., Ahn, S. H., Yoo, J. I., Chung, Y. J., Jeon, Y. K., Yoon, B. H., Kim, H. Y., Lee, S. H., Lee, J., & Hong, S. (2019). Position Statement on the Use of Bone Turnover Markers for Osteoporosis Treatment. Journal of Bone Metabolism.

4. Cremers, C., Garnero, P., Seibel, M. J. (2008). Chapter 87- Biochemical Markers of Bone Metabolism. Principles of Bone Biology (Third Edition).


This product is for research use only and is not approved for use in humans or in clinical diagnosis. ELISA Kits are guaranteed for 6 months from date of receipt.

Publications for CTX-1 ELISA Kit (NBP2-69074)(12)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: ELISA.

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Showing Publications 1 - 10 of 12. Show All 12 Publications.
Publications using NBP2-69074 Applications Species
Li X, Wu J, Kong Q et al. Targeting GDF15 as a potential therapy for low back pain originating from endplate bioRxiv 2023-02-13 (ELISA) ELISA
Chen Y, Yang C, Dai Q et al. Gold-nanosphere mitigates osteoporosis through regulating TMAO metabolism in a gut microbiota-dependent manner Journal of nanobiotechnology 2023-04-11 [PMID: 37041523] (ELISA) ELISA
Kim SY, Park GI, Park SY et al. Gulp1 deficiency augments bone mass in male�mice by affecting osteoclasts due to elevated 17?-estradiol levels Journal of cellular physiology 2023-03-04 [PMID: 36870066]
Bai J, Yu Q, Wang Y et al. Iodine-125 brachytherapy suppresses tumor growth and alters bone metabolism in a H1299 xenograft mouse model Medical oncology (Northwood, London, England) 2023-01-06 [PMID: 36607460] (ELISA) ELISA
Yang B, Gelfanov VM, El K et al. Discovery of a potent GIPR peptide antagonist that is effective in rodent and human systems Molecular metabolism 2022-11-15 [PMID: 36400403]
Sui B, Liu J, Zheng C et al. Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress International journal of oral science 2022-08-01 [PMID: 35915088]
Zhang J, Cohen A, Shen B et al. The effect of parathyroid hormone on osteogenesis is mediated partly by osteolectin Proceedings of the National Academy of Sciences of the United States of America 2021-06-22 [PMID: 34140410] (ELISA) ELISA
Lee SY, Park KH, Lee G et al. Hypoxia-inducible factor-2 alpha mediates senescence-associated intrinsic mechanisms of age-related bone loss Experimental & molecular medicine 2021-04-02 [PMID: 33811248] (ELISA, Mouse) ELISA Mouse
Li X, Wang L, Huang B et al. Targeting actin-bundling protein L-plastin as an anabolic therapy for bone loss Science Advances 2020-11-18 [PMID: 33208358] (ELISA) ELISA
Chou H, Grant MP, Bolt AM et al. Tungsten increases sex-specific osteoclast differentiation in murine bone Toxicol Sci 2020-11-04 [PMID: 33146397] (ELISA, Mouse) ELISA Mouse
Show All 12 Publications.

Review for CTX-1 ELISA Kit (NBP2-69074) (1) 51

Average Rating: 5
(Based on 1 review)

Reviews using NBP2-69074:
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 CTX-1 NBP2-69074
reviewed by:
Dongzheng Gai


Sample Testedmouse serum


CommentsThe kit works excellent for the mouse serum.

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Dongzheng Gai