CpG oligodeoxynucleotides Summary
CpG ODNs, TLR9 Ligands (human)
- Ligand Activation 5-20 ug/ml
Human CpG ODNs are used for activation of human TLR9 at a range of 5-20 ug/ml. The TLR9/NF-kB/SEAPorter HEK 293 cell line (IML-109) is a useful positive control model system for studying hTLR9 activation (Figure 1). We typically use a 96-well plate format assay using this reporter cell line
Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Please see the protocols for proper use of this product. If no protocol is available, contact technical services for assistance.
- NBP2-31139SS: 25 ug CpG Type C ODN (C792)
- NBP2-31138SS: 25 ug CpG Type C ODN (C695)
- NBP2-31137SS: 25 ug CpG Type C ODN (C274)
- NBP2-31136SS: 25 ug CpG Type A ODN (2216)
- NBP2-31134SS: 25 ug CpG Type B ODN (2006)
Alternate Names for CpG oligodeoxynucleotides
- CpG ODN (2006)
- CpG ODN
- oligodeoxynucleotides (ODN)
Unmethylated deoxycytosine-deoxyguanosine (CpG) dinucleotides are more frequently present in bacterial and viral DNA than in mammalian DNA1. CpG oligodeoxynucleotides (ODNs) are synthetic forms of oligonucleotides, which contains unmethylated CpG motifs, and can induce cellular immune responses through the activation of Toll-like receptor 9 (TLR9)2,3. There are three types (types A, B and C) of CpG ODNs, each of which acts differentially on stimulation of immune cells3-5. Type A CpG ODNs consist of a phosphodiester central CpG-containing palindromic motif and a phosphorothioate poly-G string at 3'-end. Type A CpG ODNs are high inducers for IFNa production in plasmacytoid dendritic cells (pDCs) but are low inducers for TLR9-dependent NF-kB induction. Type B CpG ODNs consist of a full phosphorothioate backbone with one or more CpG motifs. They are relatively higher inducers for TLR9-dependent NF-kB induction, strongly activating B cells, but are low inducers for IFNa production in pDCs. Type C CpG ODNs contain both features of Types A and B, which consist of a full phosphorothioate backbone and a CpG-containing palindromic motif. Type C CpG ODNs can induce high IFNa production in pDCs as well as B cell activation.
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