Cortisol Antibody

Product Discontinued

Cortisol Antibody Summary

• Immunogen: Cortisol-3-(O-carboxymethyl) oxime-BSA
• Localization: Secreted
• Specificity: NB100-62219 recognizes the glucocorticoid hormone cortisol, that is produced in the adrenal cortex and is involved in responses to stress. The following cross reactivities have been observed (number in percent): Cortisol-100, Prednisolone-38, 11-Deoxycortisol-2.5, 17a-OHP-0.4, Corticosterone-<0.1, and Cortisone-23.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Donkey
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Radioimmunoassay 1:100-1:2000

Reactivity Notes

Reacts with: Broad, Fish

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.09% Sodium Azide
• Purity: IgG purified

Alternate Names for Cortisol Antibody

• Compound F
• Cortisol
• Hydrocortisone

Background

Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.