Clostridium Difficile Toxin B Antibody (5A8-E11)

Product Discontinued

Clostridium Difficile Toxin B Antibody (5A8-E11) Summary

• Immunogen: C. difficile Toxin B
• Localization: Secreted
• Specificity: Clostridium difficile Toxin B (5A8-E11) 23 different species of Clostridia have been tested. This antibody is positive for 3 strains of C. difficile, Strain ID# 43255, 24050, and 26689. This is also tested positive for C. sordelli strain # 2037. This antibody has been tested negative for C. absonum, C. barati, C. botulinum, C. butyricum, C. carnis, C. celatum, C. chauvoei, C. colinum, C. hastiforme, C. histolyticum, C. innocuum, C. irregularis, C. leptum, C. limosum, C. malenominatum, C. novyi, C. peffringens, C. septicum, C. sporogenes, C. tetani, C. tertium and C. difficile Strain ID # 2037 as well as B. assacchrolyhcus, B. adolescentis, P. productus, R. brommii, M. elsdenii, E. coli, E. rectale, C. albicans, V. parvula, C. davisae, S. aureus and D. pigra.
• Isotype: IgG1 Kappa
• Clonality: Monoclonal
• Host: Mouse
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • N/A
  • Western Blot
• Application Notes: Use in Western blot reported in reported in scientific literature (PMID: 24039264).

Reactivity Notes

Clostridium difficile

Packaging, Storage & Formulations

• Storage: Store at -70C. Avoid freeze-thaw cycles.
• Buffer: Ascites
• Preservative: 0.1% Sodium Azide
• Concentration: This product is unpurified. The exact concentration of antibody is not quantifiable.
• Purity: Unpurified

Alternate Names for Clostridium Difficile Toxin B Antibody (5A8-E11)

• tcdA; toxB

Background

Clostridium Difficile Toxin B, also known as TcdB, is a toxin produced by Clostridium Difficile,a species of anaerobic gram-positive bacteria. Toxin B is classified as a cytotoxin and is one of the causes of antibotic-associated diarrhea and pseudomembranous colitis.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Clostridium Difficile Toxin B Antibody (NB600-1067)(3)

Publications using NB600-1067

• McKee RW, Mangalea MR, Purcell EB et al. The Second Messenger Cyclic Di-GMP Regulates Clostridium difficile Toxin Production by Controlling Expression of sigD. J Bacteriol. 2013-11-01 [PMID: 24039264] (WB, Bacteria)
• Aubry A, Hussack G, Chen W et al. Modulation of Toxin Production by the Flagellar Regulon in Clostridium difficile Infect Immun 2012-10-01 [PMID: 22851750] (WB, Bacteria)
• Goulding D, Thompson H, Emerson J et al. Distinctive profiles of infection and pathology in hamsters infected with Clostridium difficile strains 630 and B1. Infect Immun;77(12):5478-85. 2009-12-01 [PMID: 19752031]