Clostridium Difficile Toxin B Antibody (5156)

Product Discontinued

Clostridium Difficile Toxin B Antibody (5156) Summary

• Immunogen: The immunogen is specific for Clostridium difficile toxin B.
• Specificity: NBP1-21511 is specific for Clostridium difficile toxin B. No reaction is observed with toxin A.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:20-1:200

Reactivity Notes

Reacts with Bateria.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS
• Preservative: 0.1% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A purified

Alternate Names for Clostridium Difficile Toxin B Antibody (5156)

• tcdA; toxB

Background

Clostridium difficile Toxin B (tcdB or ToxB) is a glucosyltranferase which is known to inactivate Rho, Cdc42 and Rac within target cells. This toxin is encoded on a pathogenicity region of the C. difficile chromossome and is expressed during the log and stationary phases of growth in response to a variety of environmental stimuli. Specific for Toxin B of Clostridium difficile. Does not cross-react with Toxin A. Clostridium difficile is a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. Toxin B (TcdB) is a large exotoxin. Its role in disease is less well understood than that of toxin A, though it seems clear that TcdB contributes to disease. Both toxins modifies the Ras superfamily of small GTPases via glycosylation, inactivating them and leading to the disruption of vital signaling pathways in the cell.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.