Clostridium Difficile Toxin A Antibody (5155)

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Product Details

Summary
Reactivity BaSpecies Glossary
Applications ELISA
Clone
5155
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.

Order Details

Clostridium Difficile Toxin A Antibody (5155) Summary

Immunogen
Clostridium Difficile Toxin A
Specificity
This product is specific for Clostridium difficile toxin A. No reaction is observed with the following organisms:Clostridium difficile toxin B, tetanus toxoid, Pseudomonas aeruginosa and Yersinia enterocolitica Clostridium difficile is a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity
Tissue culture supernatant
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Applications/Dilutions

Dilutions
  • ELISA 1:20-1:200
Reviewed Applications
Read 1 Review rated 1
using
NB100-62471 in the following application:

Reactivity Notes

Reacts with Bacteria.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.
Purity
Tissue culture supernatant

Alternate Names for Clostridium Difficile Toxin A Antibody (5155)

  • TcdA
  • ToxA
  • Toxin A

Background

Clostridia are toxin-producing anaerobic bacteria that cause a number of serious diseases, including tetanus, botulism, and tissue infections. Clostridia normally inhabit the human intestinal tract, soil, and decaying vegetation. All species of clostridia produce toxins. Some clostridial diseases, such as botulism and the various diarrheal illnesses, result solely from the toxin without any bacterial invasion of tissue. In other clostridial diseases, such as tetanus and clostridial wound infections, there is both tissue invasion and toxin production. This antibody detects Clostridium difficile, a gram-positive motile bacterium which is the leading cause of diarrhoea in developed countries. The incidence of disease in humans varies greatly with age, spore density, and the administration of antibiotics. Toxin A (TcdA) is a large exotoxin which is an essential virulence factor for C. difficile infection. TcdA has a molecular weight of 308kD and is a glucosyltransferase, which irreversibly inactivates the Ras family of small GTPases to disrupt many important signalling pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Review for Clostridium Difficile Toxin A Antibody (NB100-62471) (1) 11

Average Rating: 1
(Based on 1 review)
We have 1 review tested in 1 species: Clostridium difficile.

Reviews using NB100-62471:
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WB
(1)
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Images Ratings Applications Species Date Details
Western Blot Clostridium Difficile Toxin A NB100-62471
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reviewed by:
Anonymous
WB Clostridium difficile 05/16/2017
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Summary

ApplicationWestern Blot
Sample TestedBacterial lysates and TCA-precipitated supernatant
SpeciesClostridium difficile
Lot0

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FAQs for Clostridium Difficile Toxin A Antibody (NB100-62471). (Showing 1 - 1 of 1 FAQ).

  1. I am seeking monoclonal antibodies specific for the C Terminal binding regions of clostridum difficile toxins A and B (aa1852-2366)?
    • I would recommend catalog # NB100-62473. Although it is a polyclonal, it is the only one that we know binds to the C-Terminal portion of the protein. The other antibodies we have against both targets are synthesized from the full length sequence. We do not routinely epitope map our antibodies so we cannot be certain where they are binding. This polyclonal is synthesized against a small 10 amino acid region of the protein so it should be highly specific to that location.

Secondary Antibodies

 

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Anonymous
05/16/2017
Application: WB
Species: Clostridium difficile

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