CEACAM18 Antibody (1057633) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 1057633
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor Plus 647

CEACAM18 Antibody (1057633) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human CEACAM-18 in direct ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CEACAM18 Antibody (1057633) [Alexa Fluor™ Plus 647]

• Carcinoembryonic Antigen-Related Cell Adhesion Molecule 18
• CEACAM-18

Background

Carcinoembryonic Antigen-related Cell Adhesion Molecule 18 (CEACAM-18) is part of the CEA protein family consisting of CEACAMs and the pregnancy-specific glycoproteins (PSGs). Both CEACAM and PSG molecules have been identified in humans and belong to the much larger glycosylphosphatidylinositol (GPI)-linked immunoglobulin (Ig) superfamily (1, 2). Mature human CEACAM-18 has a 298 amino acid (aa) extracellular domain containing 2 IgC2-like and 1 IgV-like domains, a single transmembrane domain and a short cytoplasmic tail (2). CEACAM-18 is one of only five conserved CEACAMs among mouse, rat, and human (2), but mature human CEACAM-18 has low aa sequence identify with mouse and rat at 60% and 58%, respectively. Originally discovered as a biomarker for colorectal cancer (3), CEACAMs have now been associated with numerous intracellular signaling processes including cell adhesion, cell growth, recognition and differentiation, angiogenesis, and apoptosis (4-6). While the exact function of CEACAM-18 has been yet to be elucidated, it may bind pathogen receptors or other immunoregulatory members (6). CEACAM family members were identified as the major Galectin-3 receptor candidates on human neutrophils (7). Binding of carbohydrate ligands to CEACAMs may be important in the release of proinflammatory mediators (8, 9).

1. Beauchemin, N. et al. (1999) Exp. Cell Res. 252:243.
2. Zebhauser, R. et al. (2005) Genomics 86:566.
3. Gold, P and Freedman SO, 1965) J Exp Med 122:467.
4. Obrink, B. (1997) Curr Opin Cell Biol 9:616.
5. Horst, A.K. and Wagener, C. (2004) Handb Exp Pharmacol 283.
6. Kuespert, K. et al. (2006) Curr Opin Cell Biol. 18(5):565.
7. Feuk-Lagerstedt, E. et al. (1999) J. Immunol. 163:5592.
8. Yoon, J. et al. (2007) J. Immunol. 179:8454.
9. Schröder, A.K. et al. (2006) Hum Immunol. 67:676.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.