CD40 Ligand/TNFSF5

Product Discontinued

CD40 Ligand/TNFSF5 Summary

• Host: Human
• Gene: CD40LG

Applications/Dilutions

• Application Notes: Murine L cells were stably transfected with human CD40L (L6) and freeze-dried through proprietary process. These cells are primarily intended to activate human cells through triggering of CD40 surface antigen but were also demonstrated to activate B cells from several animal species. L6 cells successfully support the differentiation of human monocyte towards the dendritic cell lineage. L6 cells are included in the Human Blood B booster and the Animal Blood B Booster kits, and support B cell growth and Ig secretion, but can also used alone for transient cultures.

Reactivity Notes

Rat, Sheep, Dog, Cat, Pig, Horse, Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Store at -20C. Avoid freeze-thaw cycles. After opening store under sterile conditions.
• Preservative: No Preservative
• Reconstitution Instructions: Resuspended L6 cells can be kept at 4C under sterilized conditions for up to 2 months.

Notes

This product is manufactured by Eurobio Scientific (formerly Dendritics) and distributed by Novus Biologicals.

Background

CD40L is the ligand for CD40, a member of the tumor necrosis factor (TNF) receptor superfamily. CD40L is expressed mainly on activated CD4+ T-lymphocytes as a single-pass type II membrane protein. Proteolytic processing of the membrane form results in a soluble secreted form of CD40L.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.

Bioinformatics

• Gene Symbol: CD40LG