Caspase-13 Antibody

Product Discontinued

Caspase-13 Antibody Summary

• Immunogen: Rabbit anti-caspase-13 polyclonal antibody was raised against a peptide corresponding to amino acids 91 to 105 of human caspase-13.
• Specificity: Casp-13 / ERICE
• Isotype: IgG
• Clonality: Polyclonal
• Host: Rabbit
• Gene: CASP4
• Purity: IgG purified

Applications/Dilutions

• Dilutions:
  • Western Blot 0.5-1 ug/ml
• Application Notes: This polyclonal antibody can be used for detection of AIF by Western blot at 0.5 to 1 ug/ml. HL60 cell lysate can be used as positive control and a 43 kDa band should be detected. It is human, mouse and rat reactive.

Reactivity Notes

This antibody is reactive against Human, Mouse, Rat

Packaging, Storage & Formulations

• Storage: Store at 4C. Do not freeze.
• Buffer: PBS
• Preservative: 0.02% Sodium Azide
• Purity: IgG purified

Alternate Names for Caspase-13 Antibody

• apoptosis-related cysteine protease
• CASP13
• Caspase13
• Caspase-13
• ERICE

Background

Apoptosis is related to many diseases and induced by a family of cell death receptors and their ligands. Cell death is finally caused by members of the caspase family of proteases and caspase activated DNases. A novel member in the caspase family was recently identified and designated ERICE (for Evolutionarily Related Interleukin-1 beta Converting Enzyme) and caspase-13 (1). Caspase-13 belongs to the ICE subfamily of caspases. Overexpression of caspase-13 induces apoptosis. Caspase-13 was activated by caspase-8, which is a key enzyme in death receptor induced apoptosis. Caspase-13 is expressed in a variety of human tissues and cell lines (1).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: CASP4