Packaging, Storage & Formulations
Store at 4C in the dark.
Please see the protocols for proper use of this product. If no protocol is available, contact technical services for assistance.
Reconstitute with 5 mg/ml enthanol with heat or 50 mg/ml DMSO with heat/sonication to desired concetration.
Ionophore is highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase.
Calcium Ionophore is an antibiotic that
possesses weak in vitro activity against gram positive
organisms. It greatly increases the ability of divalent
ions to cross biological membranes, giving it
properties as an ionophore
, and specifically forms
stable 2:1 complexes with divalent cations, rendering
these ions soluble in ordinary organic solvents. Since
Calcium Ionophore is highly selective for Ca2+
it is commonly used to increase intracellular Ca2+
levels in intact cells
. In cell culture it stimulates nitric
oxide production by calmodulin-dependent constitutive
nitric oxide synthase
. It also acts as an uncoupler of
oxidative phosphorylation and an inhibitor of
mitochondrial ATPase activity
. Calcium Ionophore
potentiates responses to NMDA but not
. It induces apoptosis in mouse lymphoma
cell line (S49) but also has been shown to block
apoptosis in other systems, such as when interleukin-3
is withdrawn from IL-3 dependent cells
. It can lower
the fractal dimension of cellular plasma membrane,
leading to cell apoptosis of SK-BR-3 human breast
cancer, and can significantly and rapidly raise the
intracellular mobile Zn2+ content, leading to apoptosis
of C6 glioma cells.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed
for 6 months from date of receipt.
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