Bacillus Anthracis Lethal Factor Antigen Antibody (LFA58)

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Product Details

Summary
Reactivity BaSpecies Glossary
Applications S-ELISA
Clone
LFA58
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Bacillus Anthracis Lethal Factor Antigen Antibody (LFA58) Summary

Immunogen
highly purified lethal factor antigen of Bacillus anthracis.
Specificity
Bacillus anthracis lethal factor.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Sandwich ELISA 1:100-1:2000
Application Notes
Best recommended pairs (capture-detection): NB100-73104 - NB100-73105

Reactivity Notes

Bacteria.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.4)
Preservative
0.09% Sodium Azide
Purity
Protein G purified

Alternate Names for Bacillus Anthracis Lethal Factor Antigen Antibody (LFA58)

  • Anthrax lethal factor
  • Anthrax lethal toxin endopeptidase component
  • Anthrax LF
  • B.anthracis lethal factor
  • bacillus anthracis lethal factor
  • Lef
  • LF

Background

The protease enzyme Lethal Factor (LF) is one of the three proteins (LF, EF & PA) composing the anthrax toxin produced by Bacillus anthracis, a bacteria which can infect many mammalian species and that may be fatal. LF is not toxic by itself, but when associated with Protective Antigen (PA), can then gain entry to cells. Once inside the cell, LF then cleaves the N terminal of most dual specificity mitogen activated protein kinase (MAPKKs or MAP2Ks) (except for MAP2K5). Cleavage invariably occurs within the N terminal proline rich region preceding the kinase domain, thus disrupting a sequence involved in directing specific protein protein interactions necessary for the assembly of signaling complexes. There may be other cytosolic targets of LF involved in cytotoxicity. The proteasome may mediate a toxic process initiated by LF in the cell cytosol involving degradation of unidentified molecules that are essential for macrophage homeostasis. This is an early step in LF intoxication, but it is downstream of the cleavage by LF of MEK1 or other putative substrates.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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