8-oxo-dG Antibody (15A3) [Unconjugated]

Expression of apoptotic factors in denervated muscle 2 weeks after denervation.(A) Expression of Bcl-2, Bad, and Bax in denervated muscle subjected to different treatment (B) Quantitative analysis of apoptotic markers in different treatment groups (C) The expression of 8-oxo-dG in normal, control, ES, and AFS group. (D) The representative of western blot analysis of 8-oxo-dG related to different treatment (n = 2) (F) Quantitative analysis of caspase-3 in different treatment groups Bar length = 100 μm. R = right, L = left, N = 6 for each group, * p<0.05 and **p<0.01indicated a statistical difference compared to the control group; # p<0.05 indicated a statistical difference as compared to the ES group. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25945496), licensed under a CC-BY license. Not internally tested by R&D Systems.

Expression of apoptotic factors in denervated muscle 2 weeks after denervation.(A) Expression of Bcl-2, Bad, and Bax in denervated muscle subjected to different treatment (B) Quantitative analysis of apoptotic markers in different treatment groups (C) The expression of 8-oxo-dG in normal, control, ES, and AFS group. (D) The representative of western blot analysis of 8-oxo-dG related to different treatment (n = 2) (F) Quantitative analysis of caspase-3 in different treatment groups Bar length = 100 μm. R = right, L = left, N = 6 for each group, * p<0.05 and **p<0.01indicated a statistical difference compared to the control group; # p<0.05 indicated a statistical difference as compared to the ES group. Image collected and cropped by CiteAb from the following publication (//pubmed.ncbi.nlm.nih.gov/25945496), licensed under a CC-BY license. Not internally tested by R&D Systems.

Expression of apoptotic factors in denervated muscle 2 weeks after denervation.(A) Expression of Bcl-2, Bad, and Bax in denervated muscle subjected to different treatment (B) Quantitative analysis of apoptotic markers in different treatment groups (C) The expression of 8-oxo-dG in normal, control, ES, and AFS group. (D) The representative of western blot analysis of 8-oxo-dG related to different treatment (n = 2) (F) Quantitative analysis of caspase-3 in different treatment groups Bar length = 100 μm. R = right, L = left, N = 6 for each group, * p<0.05 and **p<0.01indicated a statistical difference compared to the control group; # p<0.05 indicated a statistical difference as compared to the ES group. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/25945496), licensed under a CC-BY license. Not internally tested by R&D Systems.

Expression of apoptotic factors in denervated muscle 2 weeks after denervation.(A) Expression of Bcl-2, Bad, and Bax in denervated muscle subjected to different treatment (B) Quantitative analysis of apoptotic markers in different treatment groups (C) The expression of 8-oxo-dG in normal, control, ES, and AFS group. (D) The representative of western blot analysis of 8-oxo-dG related to different treatment (n = 2) (F) Quantitative analysis of caspase-3 in different treatment groups Bar length = 100 μm. R = right, L = left, N = 6 for each group, * p<0.05 and **p<0.01indicated a statistical difference compared to the control group; # p<0.05 indicated a statistical difference as compared to the ES group. Image collected and cropped by CiteAb from the following open publication (//pubmed.ncbi.nlm.nih.gov/25945496), licensed under a CC-BY license. Not internally tested by R&D Systems.

• Reactivity: All-Multi
• Applications: ELISA, IHC, ICC/IF
• Clone: 15A3
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated

8-oxo-dG Antibody (15A3) [Unconjugated] Summary

• Immunogen: 8-oxo-dG-conjugated-KLH
• Specificity: This mouse monoclonal antibody specifically binds to 8-hydroxy-2'- deoxyguanosine within DNA in H₂O₂-treated cells.
• Source: N/A
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified from ascites

Applications/Dilutions

• Dilutions:
  • ELISA
  • Immunocytochemistry 1:250 dilution
  • Immunohistochemistry 1:250 dilution

Packaging, Storage & Formulations

• Storage: Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
• Buffer: This antibody is provided as purified immunoglobulin from mouse ascites at 0.5 mg/ml in 1X PBS containing 0.1% sodium azide, 50% glycerol.
• Preservative: 0.1% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for 8-oxo-dG Antibody (15A3) [Unconjugated]

• 8-OHG
• 8oxodG
• 8-oxo-dG

Background

The production of 8-Hydroxyguanine (8-oxo-dG) is almost exclusively elicited by oxidative stress. Polymerases preferentially insert adenine opposite 8-oxo-dG. Therefore, oxidatively damaged adducts, without repair, are susceptible to G to T transitions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for 8-oxo-dG Antibody (4354-MC-050)(75)

Publications using 4354-MC-050

• Xiong, F;Yang, Y;Han, Z;Zhang, B;Kwak, K;Wang, P;Chen, Q;Wang, Z;Yang, J;Deng, X;Zou, S;Zhang, Z;You, P;Yu, B;Zhu, X; 18F-5-fluoro-aminosuberic acid PET/CT imaging of oxidative-stress features during the formation of DEN-induced rat hepatocellular carcinoma Theranostics 2025-01-01 [PMID: 39744233] (Immunohistochemistry, Rat)
• Lo, CH;Chen, S;Zhao, J;Liu, Z;Wang, B;Wang, Q;Kowal, TJ;Sun, Y; Defective Neurogenesis in Lowe Syndrome is Caused by Mitochondria Loss and Cilia-related Sonic Hedgehog Defects bioRxiv : the preprint server for biology 2024-11-01 [PMID: 39553960] (Immunocytochemistry, Human)
• Lan, T;Arastu, S;Lam, J;Kim, H;Wang, W;Wang, S;Bhatt, V;Lopes, EC;Hu, Z;Sun, M;Luo, X;Ghergurovich, JM;Su, X;Rabinowitz, JD;White, E;Guo, JY; Glucose-6-phosphate dehydrogenase maintains redox homeostasis and biosynthesis in LKB1-deficient KRAS-driven lung cancer Nature communications 2024-07-12 [PMID: 38997257] (Immunohistochemistry, Transgenic Mouse)
• Nicholson, JG;Cirigliano, S;Singhania, R;Haywood, C;Shahidi Dadras, M;Yoshimura, M;Vanderbilt, D;Liechty, B;Fine, HA; Chronic hypoxia remodels the tumor microenvironment to support glioma stem cell growth Acta neuropathologica communications 2024-03-25 [PMID: 38528608] (Immunocytochemistry, Human)
• Andreani, C;Bartolacci, C;Persico, G;Casciaro, F;Amatori, S;Fanelli, M;Giorgio, M;Galié, M;Tomassoni, D;Wang, J;Zhang, X;Bick, G;Coppari, R;Marchini, C;Amici, A; SIRT6 promotes metastasis and relapse in HER2-positive breast cancer Scientific reports 2023-12-12 [PMID: 38081972] (IHC, Mouse)
• Lan, T;Arastu, S;Wang, S;Lam, J;Wang, W;Bhatt, V;Lopes, EC;Hu, Z;Sun, M;Luo, X;Ghergurovich, JM;Li, C;Su, X;Rabinowitz, JD;White, E;Guo, JY; G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer bioRxiv : the preprint server for biology 2023-10-09 [PMID: 37873106] (IHC, Mouse)
• Han, S;Mueller, C;Wuebbolt, C;Kilcullen, S;Nayyar, V;Calle Gonzalez, B;Mahdavi Fard, A;Floss, JC;Morales, MJ;Patel, SP; Selective effects of estradiol on human corneal endothelial cells Scientific reports 2023-09-15 [PMID: 37714879] (ICC, Human)
• Roux, AE;Yuan, H;Podshivalova, K;Hendrickson, D;Kerr, R;Kenyon, C;Kelley, D; Individual cell types in C. elegans age differently and activate distinct cell-protective responses Cell reports 2023-08-01 [PMID: 37531250] (Immunohistochemistry, Rat)
• Agrez, M;Rybchyn, MS;De Silva, WGM;Mason, RS;Chandler, C;Piva, TJ;Thurecht, K;Fletcher, N;Liu, F;Subramaniam, G;Howard, CB;Blyth, B;Parker, S;Turner, D;Rzepecka, J;Knox, G;Nika, A;Hall, A;Gooding, H;Gallagher, L; An immunomodulating peptide to counteract solar radiation-induced immunosuppression and DNA damage Scientific reports 2023-07-20 [PMID: 37474630] (IHC, Mouse)
• Han, S;Mueller, C;Wuebbolt, C;Kilcullen, S;Nayyar, V;Calle Gonzalez, B;Mahdavi Fard, A;Floss, JC;Morales, MJ;Patel, SP; Selective effects of estradiol on human corneal endothelial cells bioRxiv : the preprint server for biology 2023-04-28 [PMID: 37162976] (Bioassay, Human)
• Tae-Sun Ha, Su-Bin Seong, Dong-Soo Ha, Seung Jung Kim Upregulation of NADH/NADPH oxidase 4 by angiotensin II induces podocyte apoptosis Kidney Research and Clinical Practice 2023-03-31 [PMID: 37037482]
• Chen S, Zhang P, Feng J et al. LMP1 mediates tumorigenesis through persistent epigenetic modifications and PGC1? upregulation Oncology reports 2023-03-01 [PMID: 36734290]
• Du C, Xu H, Cao C et al. Neutral amino acid transporter SLC38A2 protects renal medulla from hyperosmolarity-induced ferroptosis eLife 2023-02-01 [PMID: 36722887]
• T Xie, H Zahid, AR Ali, R Joyce, G Yang, C Winz, Y Le, R Zhou, P Furmanski, L Hu, N Suh Inhibitors of Keap1-Nrf2 protein-protein interaction reduce estrogen responsive gene expression and oxidative stress in estrogen receptor-positive breast cancer Toxicology and Applied Pharmacology, 2023-01-09;460(0):116375. 2023-01-09 [PMID: 36634873] (ICC, Human)
• SD Mhatre, J Iyer, J Petereit, RM Dolling-Bo, A Tyryshkina, AM Paul, R Gilbert, M Jensen, RJ Woolsey, S Anand, MB Sowa, DR Quilici, SV Costes, S Girirajan, S Bhattachar Artificial gravity partially protects space-induced neurological deficits in Drosophila melanogaster Cell Reports, 2022-09-06;40(10):111279. 2022-09-06 [PMID: 36070701] (IHC, Drosophila)
• M Ozaki, TD Le, YH Inoue Downregulating Mitochondrial DNA Polymerase gamma in the Muscle Stimulated Autophagy, Apoptosis, and Muscle Aging-Related Phenotypes in Drosophila Adults Biomolecules, 2022-08-11;12(8):. 2022-08-11 [PMID: 36008999] (Immunohistochemistry, Drosophila)
• S Guo, J Fang, W Xu, J Ortega, CY Liu, L Gu, Z Chang, GM Li Interplay between H3K36me3, methyltransferase SETD2, and mismatch recognition protein MutSalpha facilitates processing of oxidative DNA damage in human cells The Journal of Biological Chemistry, 2022-06-03;298(7):102102. 2022-06-03 [PMID: 35667440] (ICC, Human)
• Y Huo, A Sawant, Y Tan, AH Mahdi, T Li, H Ma, V Bhatt, R Yan, J Coleman, CF Dreyfus, JY Guo, MM Mouradian, E White, B Xia Tumor suppressor PALB2 maintains redox and mitochondrial homeostasis in the brain and cooperates with ATG7/autophagy to suppress neurodegeneration PloS Genetics, 2022-04-11;18(4):e1010138. 2022-04-11 [PMID: 35404932] (IHC, Transgenic Mouse)
• N Kumar, AF Theil, V Roginskaya, Y Ali, M Calderon, SC Watkins, RP Barnes, PL Opresko, A Pines, H Lans, W Vermeulen, B Van Houten Global and transcription-coupled repair of 8-oxoG is initiated by nucleotide excision repair proteins Nature Communications, 2022-02-21;13(1):974. 2022-02-21 [PMID: 35190564] (ICC, Human)
• A Behrouzi, H Xia, EL Thompson, MR Kelley, JC Fehrenbach Oxidative DNA Damage and Cisplatin Neurotoxicity Is Exacerbated by Inhibition of OGG1 Glycosylase Activity and APE1 Endonuclease Activity in Sensory Neurons International Journal of Molecular Sciences, 2022-02-08;23(3):. 2022-02-08 [PMID: 35163831] (ICC, Rat)
• Hong Yu, Yanbin Niu, Guohua Jia, Yujie Liang, Baolin Chen, Ruoyu Sun et al. Maternal diabetes-mediated RORA suppression in mice contributes to autism-like offspring through inhibition of aromatase Communications Biology 2022-01-13 [PMID: 35027651]
• Teun M. Klein Gunnewiek, Anouk H.A. Verboven, Iris Pelgrim, Mark Hogeweg, Chantal Schoenmaker, Herma Renkema et al. Sonlicromanol improves neuronal network dysfunction and transcriptome changes linked to m.3243A>G heteroplasmy in iPSC-derived neurons Stem Cell Reports 2021-09-01 [PMID: 34329596]
• K Linda, EI Lewerissa, AHA Verboven, M Gabriele, M Frega, TM Klein Gunn, L Devilee, E Ulferts, M Hommersom, A Oudakker, C Schoenmake, H van Bokhov, D Schubert, G Testa, DA Koolen, BBA de Vries, N Nadif Kasr Imbalanced autophagy causes synaptic deficits in a human model for neurodevelopmental disorders Autophagy, 2021-07-21;0(0):20-Jan. 2021-07-21 [PMID: 34286667] (ICC, Human)
• Weiguo Xie, Xueqing Zhou, Weigang Hu, Zhigang Chu, Qiongfang Ruan, Haimou Zhang et al. Pterostilbene accelerates wound healing by modulating diabetes-induced estrogen receptor beta suppression in hematopoietic stem cells Burns & Trauma 2021-02-22 [PMID: 33654697]
• Jianbo Liu, Yujie Liang, Xing Jiang, Jianchang Xu, Yumeng Sun, Zichen Wang et al. Maternal Diabetes-Induced Suppression of Oxytocin Receptor Contributes to Social Deficits in Offspring Frontiers in Neuroscience 2021-02-09 [PMID: 33633538]
• S Tao, Y Yang, J Li, H Wang, Y Ma Bixin Attenuates High-Fat Diet-Caused Liver Steatosis and Inflammatory Injury through Nrf2/PPAR&amp;alpha Signals Oxidative Medicine and Cellular Longevity, 2021-02-02;2021(0):6610124. 2021-02-02 [PMID: 33603948] (IHC, Mouse)
• Zhen Wang, Jérôme Maluenda, Laurène Giraut, Thibault Vieille, Andréas Lefevre, David Salthouse et al. Detection of genetic variation and base modifications at base-pair resolution on both DNA and RNA Communications Biology 2021-01-29 [PMID: 33514840]
• F Wang, Y Zhang, J Shen, B Yang, W Dai, J Yan, S Maimouni, HQ Daguplo, S Coppola, Y Gao, Y Wang, Z Du, K Peng, H Liu, Q Zhang, F Tang, P Wang, S Gao, Y Wang, WX Ding, G Guo, F Wang, WX Zong The ubiquitin E3 ligase TRIM21 promotes hepatocarcinogenesis by suppressing the p62-Keap1-Nrf2 antioxidant pathway Cellular and Molecular Gastroenterology and Hepatology, 2021-01-19;0(0):. 2021-01-19 [PMID: 33482392] (IHC, Mouse)
• Christina A. Wicker, Brian G. Hunt, Sunil Krishnan, Kathryn Aziz, Shobha Parajuli, Sarah Palackdharry et al. Glutaminase inhibition with telaglenastat (CB-839) improves treatment response in combination with ionizing radiation in head and neck squamous cell carcinoma models Cancer Letters 2021-04-01 [PMID: 33450358]
• J Lee, AR Oh, HY Lee, YA Moon, HJ Lee, JY Cha Deletion of KLF10 Leads to Stress-Induced Liver Fibrosis upon High Sucrose Feeding International Journal of Molecular Sciences, 2020-12-30;22(1):. 2020-12-30 [PMID: 33396939] (IHC, Mouse)
• Dongfang Xiang, Min Zhao, Xiaofan Cai, Yongxia Wang, Lei Zhang, Helen Yao et al. Betulinic Acid Inhibits Endometriosis Through Suppression of Estrogen Receptor beta Signaling Pathway Front Endocrinol (Lausanne) 2020-12-10 [PMID: 33362719]
• Anna Fracassi, Michela Marcatti, Olga Zolochevska, Natalie Tabor, Randall Woltjer, Sandra Moreno et al. Oxidative Damage and Antioxidant Response in Frontal Cortex of Demented and Nondemented Individuals with Alzheimer's Neuropathology The Journal of Neuroscience 2021-01-20 [PMID: 33239403]
• Machiela E, Jeloka R, Caron NS et al. The interaction of aging and oxidative stress contributes to pathogenesis in mouse and human Huntington disease neurons Front Aging Neurosci 11/16/2020 [PMID: 33192449]
• Jianping Lu, Meifang Xiao, Xiaoling Guo, Yujie Liang, Min Wang, Jianchang Xu et al. Maternal Diabetes Induces Immune Dysfunction in Autistic Offspring Through Oxidative Stress in Hematopoietic Stem Cells Frontiers in Psychiatry 2020-09-03 [PMID: 33101089] (Immunocytochemistry, Mouse)
• S Sengupta, H Wang, C Yang, B Szczesny, ML Hegde, S Mitra Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription Proc. Natl. Acad. Sci. U.S.A., 2020-08-21;0(0):. 2020-08-21 [PMID: 32826329] (ChIP, Co-Immunoprecipitation, Human)
• A Pezone, ML Taddei, A Tramontano, J Dolcini, FL Boffo, M De Rosa, M Parri, S Stinziani, G Comito, A Porcellini, G Raugei, D Gackowski, E Zarakowska, R Olinski, A Gabrielli, P Chiarugi, EV Avvediment Targeted DNA oxidation by LSD1-SMAD2/3 primes TGF-&amp;beta1/ EMT genes for activation or repression Nucleic Acids Res., 2020-09-18;0(0):. 2020-09-18 [PMID: 32697292]
• L Yuan, R Mishra, H Patel, S Alanazi, X Wei, Z Ma, JT Garrett BRAF Mutant Melanoma Adjusts to BRAF/MEK Inhibitors via Dependence on Increased Antioxidant SOD2 and Increased Reactive Oxygen Species Levels Cancers (Basel), 2020-06-23;12(6):. 2020-06-23 [PMID: 32585852] (ICC, Human)
• V Gomez Godi, S Kabbara, A Sherman, T Wu, S Cohen, X Kong, JL Maravillas, Z Shi, D Preece, K Yokomori, MW Berns DNA damage induced during mitosis undergoes DNA repair synthesis PLoS ONE, 2020-04-28;15(4):e0227849. 2020-04-28 [PMID: 32343690] (ICC, Human)
• Dongfang Xiang, Jianping Lu, Chongxia Wei, Xiaofan Cai, Yongxia Wang, Yujie Liang et al. Berberine Ameliorates Prenatal Dihydrotestosterone Exposure-Induced Autism-Like Behavior by Suppression of Androgen Receptor Frontiers in Cellular Neuroscience 2020-04-09 [PMID: 32327976]
• D'Adamo S, Cetrullo S, Guidotti S et al. Spermidine rescues the deregulated autophagic response to oxidative stress of osteoarthritic chondrocytes Free Radic. Biol. Med. 4/16/2020 [PMID: 32305648]
• I Martinelli, D Tomassoni, M Moruzzi, P Roy, C Cifani, F Amenta, SK Tayebati Cardiovascular Changes Related to Metabolic Syndrome: Evidence in Obese Zucker Rats Int J Mol Sci, 2020-03-16;21(6):. 2020-03-16 [PMID: 32188150] (IHC, Human)
• S Maynard, G Keijzers, M Akbari, MB Ezra, A Hall, M Morevati, M Scheibye-K, S Gonzalo, J Bartek, VA Bohr Lamin A/C promotes DNA base excision repair Nucleic Acids Res., 2019-12-16;0(0):. 2019-12-16 [PMID: 31647095] (ICC, Mouse)
• Y Wu, MM Konaté, J Lu, H Makhlouf, R Chuaqui, S Antony, JL Meitzler, MJ Difilippan, H Liu, A Juhasz, G Jiang, I Dahan, K Roy, JH Doroshow IL-4 and IL-17A Cooperatively Promote Hydrogen Peroxide Production, Oxidative DNA Damage, and Upregulation of Dual Oxidase 2 in Human Colon and Pancreatic Cancer Cells J. Immunol., 2019-09-23;0(0):. 2019-09-23 [PMID: 31548328] (ICC, Human)
• DQ Tan, Y Li, C Yang, J Li, SH Tan, DWL Chin, A Nakamura-I, H Yang, T Suda PRMT5 Modulates Splicing for Genome Integrity and Preserves Proteostasis of Hematopoietic Stem Cells Cell Rep, 2019-02-26;26(9):2316-2328.e6. 2019-02-26 [PMID: 30811983] (ICC, Transgenic Mouse)
• CG Li, C Mahon, NM Sweeney, E Verschuere, V Kantamani, D Li, JK Hennigs, DP Marciano, I Diebold, O Abu-Halawa, M Elliott, S Sa, F Guo, L Wang, A Cao, C Guignabert, J Sollier, NP Nickel, M Kaschwich, KA Cimprich, M Rabinovitc PPAR? Interaction with UBR5/ATMIN Promotes DNA Repair to Maintain Endothelial Homeostasis Cell Rep, 2019-01-29;26(5):1333-1343.e7. 2019-01-29 [PMID: 30699358] (ICC, Human)
• X Li, G Wu, F Han, K Wang, X Bai, Y Jia, Z Li, W Cai, W Zhang, L Su, D Hu SIRT1 activation promotes angiogenesis in diabetic wounds by protecting endothelial cells against oxidative stress Arch. Biochem. Biophys., 2018-11-17;661(0):117-124. 2018-11-17 [PMID: 30458128] (IHC, Human)
• WJ Yi, MY Su, Y Shi, S Jiang, SZ Xu, TC Lei Degraded melanocores are incompetent to protect epidermal keratinocytes against UV damage Cell Cycle, 2018-04-25;0(0):1-40. 2018-04-25 [PMID: 29623762] (ICC, Human)
• Piao L, Choi J, Kwon G, Ha H Endogenous catalase delays high-fat diet-induced liver injury in mice. Korean J Physiol Pharmacol, 2017-04-21;21(3):317-325. 2017-04-21 [PMID: 28461774]
• Trachana V, Petrakis S, Fotiadis Z, Siska E, Balis V, Gonos E, Kaloyianni M, Koliakos G Human mesenchymal stem cells with enhanced telomerase activity acquire resistance against oxidative stress-induced genomic damage. Cytotherapy, 2017-04-25;19(7):808-820. 2017-04-25 [PMID: 28454681]
• CC Kuo, HL Su, TL Chang, CY Chiang, ML Sheu, FC Cheng, CJ Chen, J Sheehan, HC Pan Prevention of Axonal Degeneration by Perineurium Injection of Mitochondria in a Sciatic Nerve Crush Injury Model Neurosurgery, 2017-03-01;80(3):475-488. 2017-03-01 [PMID: 28362972] (ICC, Western Blot, Rat)
• Hsieh T, Lee H, Hameed M, Pascual-Leone A, Hensch T, Rotenberg A Trajectory of Parvalbumin Cell Impairment and Loss of Cortical Inhibition in Traumatic Brain Injury. Cereb Cortex, 2017-12-01;27(12):5509-5524. 2017-12-01 [PMID: 27909008]
• Sohn M, Kim K, Uddin M, Lee G, Hwang I, Kang H, Kim H, Lee J, Ha H Delayed treatment with fenofibrate protects against high-fat diet-induced kidney injury in mice: the possible role of AMPK autophagy. Am J Physiol Renal Physiol, 2016-07-27;312(2):F323-F334. 2016-07-27 [PMID: 27465995]
• Thaete L, Khan S, Neerhof M Endothelin Receptor A Antagonism Prevents Damage to Glycogen-Rich Placental Cells Following Uterine Ischemia-Reperfusion in the Rat. Reprod Sci, 2016-04-28;23(11):1518-1525. 2016-04-28 [PMID: 27130231]
• Llorente-Folch I, Rueda C, Perez-Liebana I, Satrustegui J, Pardo B L-Lactate-Mediated Neuroprotection against Glutamate-Induced Excitotoxicity Requires ARALAR/AGC1. J Neurosci, 2016-04-20;36(16):4443-56. 2016-04-20 [PMID: 27098689]
• Polyzos A, Holt A, Brown C, Cosme C, Wipf P, Gomez-Marin A, Castro M, Ayala-Pena S, McMurray C Mitochondrial targeting of XJB-5-131 attenuates or improves pathophysiology in HdhQ150 animals with well-developed disease phenotypes. Hum Mol Genet, 2016-02-21;25(9):1792-802. 2016-02-21 [PMID: 26908614]
• Pillai V, Bindu S, Sharp W, Fang Y, Kim G, Gupta M, Samant S, Gupta M Sirt3 protects mitochondrial DNA damage and blocks the development of doxorubicin-induced cardiomyopathy in mice. Am J Physiol Heart Circ Physiol, 2016-02-12;310(8):H962-72. 2016-02-12 [PMID: 26873966]
• Long M, Rojo de la Vega M, Wen Q, Bharara M, Jiang T, Zhang R, Zhou S, Wong P, Wondrak G, Zheng H, Zhang D An Essential Role of NRF2 in Diabetic Wound Healing. Diabetes, 2015-12-30;65(3):780-93. 2015-12-30 [PMID: 26718502]
• Paquet N, Adams M, Leong V, Ashton N, Touma C, Gamsjaeger R, Cubeddu L, Beard S, Burgess J, Bolderson E, O'Byrne K, Richard D hSSB1 (NABP2/ OBFC2B) is required for the repair of 8-oxo-guanine by the hOGG1-mediated base excision repair pathway. Nucleic Acids Res, 2015-08-10;43(18):8817-29. 2015-08-10 [PMID: 26261212]
• Chen Y, Harris R, Hatahet Z, Chou K Ablation of XP-V gene causes adipose tissue senescence and metabolic abnormalities. Proc Natl Acad Sci U S A, 2015-08-03;112(33):E4556-64. 2015-08-03 [PMID: 26240351]
• Chen C, Cheng F, Su H, Sheu M, Lu Z, Chiang C, Yang D, Sheehan J, Pan H Improved neurological outcome by intramuscular injection of human amniotic fluid derived stem cells in a muscle denervation model. PLoS ONE, 2015-05-06;10(5):e0124624. 2015-05-06 [PMID: 25945496] (IHC, Western Blot, Rat)
• Long M, Tao S, Rojo de la Vega M, Jiang T, Wen Q, Park S, Zhang D, Wondrak G Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium-induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde. Cancer Prev Res (Phila), 2015-02-23;8(5):444-54. 2015-02-23 [PMID: 25712056]
• Xie X, Koh J, Price S, White E, Mehnert J Atg7 Overcomes Senescence and Promotes Growth of BrafV600E-Driven Melanoma. Cancer Discov, 2015-02-11;5(4):410-23. 2015-02-11 [PMID: 25673642]
• Thompson B, Halliday G, Damian D Nicotinamide enhances repair of arsenic and ultraviolet radiation-induced DNA damage in HaCaT keratinocytes and ex vivo human skin. PLoS ONE, 2015-02-06;10(2):e0117491. 2015-02-06 [PMID: 25658450]
• Abdou I, Poirier G, Hendzel M, Weinfeld M DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair. Nucleic Acids Res, 2014-12-24;43(2):875-92. 2014-12-24 [PMID: 25539916]
• Ye Cui, Julie Wilder, Cecilia Rietz, Andrew Gigliotti, Xiaomeng Tang, Yuanyuan Shi et al. Radiation-Induced Impairment in Lung Lymphatic Vasculature Lymphatic Research and Biology 2014-12-01 [PMID: 25412238]
• Tao S, Wang S, Moghaddam S, Ooi A, Chapman E, Wong P, Zhang D Oncogenic KRAS confers chemoresistance by upregulating NRF2. Cancer Res, 2014-10-22;74(24):7430-41. 2014-10-22 [PMID: 25339352]
• Kilarkaje N, Al-Bader M Diabetes-induced oxidative DNA damage alters p53-p21CIP1/Waf1 signaling in the rat testis. Reprod Sci, 2014-05-14;22(1):102-12. 2014-05-14 [PMID: 24828139]
• Wu T, Zhao F, Gao B, Tan C, Yagishita N, Nakajima T, Wong P, Chapman E, Fang D, Zhang D Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis. Genes Dev, 2014-03-17;28(7):708-22. 2014-03-17 [PMID: 24636985]
• Mishra P, Raghuram G, Jain D, Jain S, Khare N, Pathak N Mitochondrial oxidative stress-induced epigenetic modifications in pancreatic epithelial cells. Int J Toxicol, 2014-02-20;33(2):116-29. 2014-02-20 [PMID: 24563415]
• Coulter J, O'Driscoll C, Bressler J Hydroquinone increases 5-hydroxymethylcytosine formation through ten eleven translocation 1 (TET1) 5-methylcytosine dioxygenase. J Biol Chem, 2013-08-12;288(40):28792-800. 2013-08-12 [PMID: 23940045]
• Nikolakopoulou Z, Nteliopoulos G, Michael-Titus A, Parkinson E Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Carcinogenesis, 2013-07-26;34(12):2716-25. 2013-07-26 [PMID: 23892603]
• Hassona Y, Cirillo N, Lim K, Herman A, Mellone M, Thomas G, Pitiyage G, Parkinson E, Prime S Progression of genotype-specific oral cancer leads to senescence of cancer-associated fibroblasts and is mediated by oxidative stress and TGF-beta. Carcinogenesis, 2013-01-27;34(6):1286-95. 2013-01-27 [PMID: 23358854]
• Surjana D, Halliday G, Damian D Nicotinamide enhances repair of ultraviolet radiation-induced DNA damage in human keratinocytes and ex vivo skin. Carcinogenesis, 2013-01-24;34(5):1144-9. 2013-01-24 [PMID: 23349012]
• Bock F, Shahzad K, Wang H, Stoyanov S, Wolter J, Dong W, Pelicci P, Kashif M, Ranjan S, Schmidt S, Ritzel R, Schwenger V, Reymann K, Esmon C, Madhusudhan T, Nawroth P, Isermann B Activated protein C ameliorates diabetic nephropathy by epigenetically inhibiting the redox enzyme p66Shc. Proc Natl Acad Sci U S A, 2012-12-24;110(2):648-53. 2012-12-24 [PMID: 23267072]
• Lim J, Luderer U Oxidative damage increases and antioxidant gene expression decreases with aging in the mouse ovary. Biol. Reprod., 2010-12-08;84(4):775-82. 2010-12-08 [PMID: 21148108] (IHC-Fr, Mouse)