17-DMAG

Product Image: 17-DMAG [NB110-81562] - Chemical structure of 17-DMAG (NB110-81562), a 17-DMAG. Molecular Formula: C32H48N4O8. Molecular Weight: 616.8 g/mol.

Product Discontinued

17-DMAG Summary

• Specificity: 17-DMAG Compound

Applications/Dilutions

• Dilutions:
  • Product Image
• Application Notes: Synthetic 17-DMAG Soluble in DMSO (>25mg/mL) and ethanol (10mg/mL) Purple solid

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.

Background

17-DMAG is a water soluble & cell-permeable analog of Geldanamycin and 17-AAG (1). It binds to the APTase site of human Hsp90a with high affinity, has cytotoxic activity against many cancer cell lines (2), and acts as angiogenesis inhibitor (3). This Hsp90 inhibitor shows promise in preclinical models. 17-DMAG has excellent bioavailability, is widely distributed to tissues, and is quantitatively metabolized much less than is 17-AAG.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Support products are guaranteed for 6 months from date of receipt.