Programmed cell death is a process that can either be regulatory or as a result of an external stress on a system of the body. There are two forms of programmed cell death: apoptosis and autophagy. Both forms undergo multiple cascades that lead to the death of a cell, and they both must receive some intrinsic or extrinsic signal to initiate the process. In apoptosis, DNA lesions induce the intrinsic pathway, while several factors including TNF-alpha and the Fas ligand located on T cells are extrinsic factors that initiate the pathway of cellular fragmentation and blebbing into apoptotic bodies. In the case of autophagy, the kinase mTOR is an important component, for when it is not activated it promotes the degradation of damaged cellular organelles. Programmed cell death can be either beneficial to a person, in cases such as tissue shaping and development as well as inhibiting the growth of malignant tumors, or it can be harmful, as shown in degenerative diseases including Parkinson’s disease.
Programmed Cell Death Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Programmed Cell Death below!
For more information on how to use Laverne, please read the How to Guide.
We have 2600 products for the study of the Programmed Cell Death Pathway that can be applied to Flow Cytometry, Western Blot, Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.