Nuclear import, or the transfer of material from the cytoplasm into the cell, can happen in two ways. Smaller molecules can enter the nucleus through the pore complexes through the simple process of diffusion, but larger molecules require the help of a nuclear import receptor, or importin. The importins bind with the transferable material (cargo) and pass through the nuclear pore complex and into the nucleus. Once inside, Ran-GTP binds to the complex, releasing from the cargo from the importin. The importin and Ran-GTP move back into the cytoplasm, where they are separated and Ran-GTP is hydrolyzed to Ran-GDP via a GTPase activating protein. The Ran-GDP is able to move back into the nucleus where it is phosphorylated by a guanine nucleotide exchange factor and is able to start the process over again.
Nuclear Import Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Import below!
For more information on how to use Laverne, please read the How to Guide.
We have 1450 products for the study of the Nuclear Import Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.