Nuclear export, or the transfer of material out of the nucleus into the cytoplasm, occurs with the binding of a G-protein called Ran-GTP to a nuclear export factor, or exportin. The binding of Ran-GTP causes a confirmation change in the exportin, which allows the transferable material, or cargo, to also bind to the export factor. The entire complex then moves out of the nucleus through the nuclear pore, and the Ran-GTP is hydrolyzed to Ran-GDP, which causes the entire complex to come apart. Both the nuclear export factor and the Ran-GDP return to the nucleus to begin the process again, as a guanine exchange factor located in the nucleus is able to turn Ran-GDP back to its active GTP form.
Nuclear Export Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Export below!
For more information on how to use Laverne, please read the How to Guide.
We have 1758 products for the study of the Nuclear Export Pathway that can be applied to Western Blot, Flow Cytometry, Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry, Immunocytochemistry/Immunofluorescence from our catalog of antibodies and ELISA kits.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.