Nuclear export, or the transfer of material out of the nucleus into the cytoplasm, occurs with the binding of a G-protein called Ran-GTP to a nuclear export factor, or exportin. The binding of Ran-GTP causes a confirmation change in the exportin, which allows the transferable material, or cargo, to also bind to the export factor. The entire complex then moves out of the nucleus through the nuclear pore, and the Ran-GTP is hydrolyzed to Ran-GDP, which causes the entire complex to come apart. Both the nuclear export factor and the Ran-GDP return to the nucleus to begin the process again, as a guanine exchange factor located in the nucleus is able to turn Ran-GDP back to its active GTP form.
Nuclear Export Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Nuclear Export below!
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We have 1394 products for the study of the Nuclear Export Pathway that can be applied to Chromatin Immunoprecipitation, Flow Cytometry, Western Blot, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.