Necrosis is a form a premature cell death that, unlike apoptosis, is not programmed or regulated. This form of cell death most often occurs from conditions in the environment that may result in injuries, infections, hypoxia, toxin exposure, and nutrient deprivation, as well as diseases and disorders including Alzheimer’s disease, amyotrophic lateral sclerosis, and epilepsy. The mechanism by which necrotic cell death occurs begins with receptors that cause the cell to swell until the membrane loses its integrity, which results in the cellular material being deposited into the extracellular space. This initiates an inflammatory response and the buildup of dead tissues around the site of the cell death. There are five kinds of buildup, coagulative (a buildup of gel), liquefactive (a buildup of liquid), caseous (a buildup of gel and liquid), fat (resulting from the necrosis of fat tissue), and fibrinoid (the result of vascular damage).
Necrotic Cell Death Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Necrotic Cell Death below!
For more information on how to use Laverne, please read the How to Guide.
We have 2223 products for the study of the Necrotic Cell Death Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.