Interkinetic nuclear migration is a phenomenon that occurs during the development of neuroepithelia, which are tissues made from neuroepithelial progenitor cells. Mitosis of these cells in order to generate more tissue occurs on the ventricular surface, or apical side, of the cells. The nuclei of these cells are able to move from the basal to apical sides of the cell and vice versa, and they do so during the cell cycle in order to be in the correct location during each separate phase. Defects in the process of interkinetic nuclear migration can lead to problems with neurogenesis as well as an unfavorable ratio of neuroepithelial progenitor cell fates.
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