Insulin is a peptide hormone that is responsible for helping with the regulation of carbohydrate and fat metabolism, as it causes the cells of various tissues to absorb glucose in various forms from the bloodstream. Insulin is produced in the beta cells of the islets of Langerhans located in the pancreas, and is ready to be released into the body once it is cleaved from its signal peptide. Once glucose enters the body, it migrates to the pancreas an enters the beta cell, which leads to membrane depolarization and opens the calcium channels, allowing calcium to flow into the cell. The increase of calcium inside the cell initiates the secretion of insulin through secretory vesicles that fuse with the cell membrane, and insulin enters the bloodstream and begins its job of regulating blood and cell glucose levels. Deficiencies in insulin or resistance to the protein can lead to diseases including diabetes mellitus and polycystic ovary syndrome.
Insulin Secretion Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Insulin Secretion below!
For more information on how to use Laverne, please read the How to Guide.
We have 1239 products for the study of the Insulin Secretion Pathway that can be applied to Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.