Apoptosis is a form of programmed cell death, which can be either a developmental process or a response from the human immune system. During apoptosis, the cell undergoes changes including chromosomal condensation, nuclear and chromosomal DNA fragmentation, and blebbing. There are two mechanisms used in the induction of apoptosis, via intrinsic and extrinsic pathways. The intrinsic pathway occurs when irreparable DNA lesions are found in the nucleus, and a number of cascades occur, ultimately leading to the activation of caspase-9 to cleave more procaspases and destroy the cellular components. The extrinsic pathway is initiated by the binding of an extracellular component, such as TNF-alpha or the Fas ligand on T cells, which causes a death domain to form inside the cell. The death domain activated FADD, which in turn cleaves procaspase-8 to form the active caspase-8 protein, which catalyzes a proteolytic cascade, resulting in the caspase-3 protein cleaving ICAD into DNAase, which works to degrade the chromatin and other cellular components affected in apoptosis. Current research is being done to find a chemical induction of apoptosis to target diseased cells such as cancer cells.
Induction Of Apoptosis Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Induction Of Apoptosis below!
For more information on how to use Laverne, please read the How to Guide.
We have 2845 products for the study of the Induction Of Apoptosis Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry, Chromatin Immunoprecipitation (ChIP) from our catalog of antibodies and ELISA kits.
PRODUCT AVAILABILITY: Update Regarding the Evolving COVID-19 Situation
Bio-Techne appreciates the critical role that you and our products and services play in research efforts to further scientific innovation and discovery. We are continually assessing our manufacturing and supplier capabilities during the COVID-19 situation and are implementing precautionary measures to ensure uninterrupted supply of products and services. Currently, and as we abide by local shelter in place orders across the world, we are fully operational and do not anticipate any material supply disruptions across our Bio-Techne brands and product lines. As the situation evolves, our goal is to utilize preventive measures to reduce the threat that COVID-19 poses to our ability to meet the needs of our customers globally.