The Hippo, or SWH, pathway works to control organ size through the mechanisms of promoting apoptosis while down-regulating cell proliferation. The Hpo signaling molecule initiates a cascade of the SWH pathway by phosphorylating the protein kinase Wts, which has been shown to regulate the growth and development of cells. Wts then phosphorylates and inactivated the transcriptional co-activators Yki, YAP, and TAZ. In organs of low cell densities, these co-activators initiate the transcription factors that allow for proliferation to occur. The Hippo pathway occurs when the cell densities are higher, in most cases when the organ has finished its growth or, in some cases, regeneration. Abnormal rates and functions of the Hippo pathway can lead to a number of disorders such as tumor growth and progression when Yki/YAP/TAZ are unsuccessfully inactivated.
Hippo Signaling Cascade Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Hippo Signaling Cascade below!
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We have 346 products for the study of the Hippo Signaling Cascade Pathway that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.