Angiogenesis is the process of the formation of new blood vessels from those that already exist. There are multiple factors that work as angiogenic stimulants, including FGF, TGF-beta, and VEGF, which results in the MAPK pathway to initiate the growth process. MMPs are also important in angiogenesis, as they degrade the extracellular matrix and allow for the new blood vessels to grow from this location. There are two methods of angiogenesis: sprouting angiogenesis, where new cells grow off of a blood vessel and fuse together to form a shared lumen, and intussusceptive angiogenesis, where the capillary wall moves into the lumen and causes the blood vessel to split into two. Angiogenesis is an important function in the oxygenation of tissues, and can help in various functions including wound healing and the treatment of vascular diseases such as heart disease, high blood pressure, and diabetes. An abnormal rate of angiogenesis, however, can cause many problems including the proliferation of cancerous tumors, diabetic ulcers, and cardiovascular diseases. Many scientists have studied factors of angiogenesis, and treatments have been created that involve either the inhibition or activation of blood vessel growth.
Angiogenesis Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Angiogenesis below!
For more information on how to use Laverne, please read the How to Guide.
We have 3299 products for the study of the Angiogenesis Pathway that can be applied to Western Blot, Flow Cytometry, Chromatin Immunoprecipitation, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.