Cell Death Research Tools

cell death
 

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Novus Cell Death Research Tools

Viability Dyes
DAPI Cell impermeant nuclear stain. Will only enter dead/dying cells with compromised membranes and fluoresce (Commonly excited by the UV laser or weakly by the 405nm violet laser and emits at 455nm)
Propidium Iodide Cell impermeant nuclear stain. Will only enter dead/dying cells with compromised membranes and fluoresce (Commonly excited by the 488nm blue laser and emits in FL2. Not compatible with PE)
Calcein AM Cell permeant dye that is cleaved by esterases and fluoresces in live but not dead cells. (Excited by the 488nm blue laser and emits in FL1)
Calcein Blue AM Mechanistically identical to Calcein AM but with different spectral properties (Excited by the UV laser and emits at 450nm similarly to DyLight 350)
 
Annexin Based Reagents
Bind phosophatidylserine (PS) which is externalized in apoptotic cells.
Annexin V Binds PS irreversibly. Available in multiple formats (APC, FITC, Biotin) for multicolor flow panels.
pSIVA Binds PS reversibly and fluoresces in FL1 when bound. Allows for real-time tracking of apoptosis and detection of the reversibility of early steps in the apoptotic cascade.
 
DNA Fragmentation Detection (TUNEL)
TUNEL assay kits label DNA strand breaks and also include the viability dye PI. Kits are assay specific.
For Flow Cytometry
For Immunofluorescence
For Immunohistochemistry
 
Cell Death and Cell Survival Antibodies
For the study of individual pathways and targets important to apoptosis.
Available in 10+ fluorophore options to facilitate multicolor panel design.
Cell Death Cell Survival
Caspases Survivin
Cytochrome C Livin
PARP Heat Shock Proteins
SMAC/Diablo Bcl-2
Bax Bcl-Xl
Beclin IAPs
Apaf-1 A20
Fas / FasL Growth Factors
FADD FLIP
And many others...

 

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