NK2R Products

Description

The Neurokinins, also known as Tachykinins, belong to an evolutionary conserved family of peptide neurotransmitters that share a c-terminal sequence and have an established role in neurotransmission. The mammalian tachykinins include substance P (NK1), neurokinin A (NKA) and neurokinin B (NKB) which exert their effects by binding to specific receptors. Tachykinin peptides are important in the mediation of many physiological and pathological processes including inflammation, pain, migraine headache and allergy induced asthma.

Three tachykinin receptor types have been characterized, NK-1, NK-2 and NK-3 which have preferential affinities for SP, NKA and NKB respectively. All three receptors share a high degree of sequence homology, have seven transmembrane spanning domains and similar signal transduction mechanisms (e.g. G-protein coupled activation of phospholipase C).

Bioinformatics

Uniprot	NP_001048.2 Human P21452 Human
Product By Gene ID	6865
Alternate Names	Neurokinin A receptor NK2RNK-2 receptor NKNARseven transmembrane helix receptor SKRneurokinin 2 receptor substance-K receptor TAC2Rsubstance K receptor tachykinin receptor 2NK-2R

Research Areas for NK2R

Find related products by research area and learn more about each of the different research areas below.

GPCR
Neuronal Cell Markers
Neuroscience
Neurotransmission