Necroptosis Pathway

Necroptosis is a programmed form of necrotic cell death which has been considered a form of passive cell death through regulated cell signaling pathways. The concept of necroptosis came from the discovery that TNFa-mediated necrosis can be inhibited by a specific inhibitor of RIP1 kinase, necrostatin-1. Necroptosis has now been established as a regulated necrotic cell death pathway controlled by RIP1 and RIP3 kinases. Necroptosis plays a role in various pathological forms of cell death, including ischemic brain injury, neurodegenerative diseases and viral infections.

autophagy pathway

Explore Your Pathways With Novus Explorer! This free bioinformatics tool is designed to facilitate scientific exploration of related genes, diseases and pathways based on co-citations.

Novus Biologicals offers a variety of top quality antibodies and proteins for necroptosis research. Some of our most popular autophagy research products are included below. Please follow the protein name links for more details.

Necroptosis Signaling Pathway Products

Caspase 4 Caspase 8 FADD PARP
Noxa NFkB p65 RIPK1 RIPK3