mTOR Signaling Pathway

mTOR Signaling Pathway

The mTor Pathway is a intercellular signaling pathway responsible for the regulation of apoptosis. It is regulated by a wide variety of cellular signals, including mitogenic growth factors, hormones such as Insulin, nutrients (amino acids, glucose), cellular energy levels, and stress conditions such as hypoxia. The mTOR (Mammalian Target of Rapamycin) kinase is the central modulator of proliferative signal transduction, whose activation begins a phosphorylation cascade that induces cell growth and proliferation. In addition, activation of the mTOR pathway also promotes cell survival and angiogenesis, and involves in suppression of autophagy induction. Aberrant mTOR signaling is involved in many disease states including cancer, cardiovascular disease and metabolic disorders.

Fully explore the mTOR pathway, proteins and diseases using our Novus Explorer bioinformatics tool.

Novus offers a wide variety of research reagents to the mTOR pathway proteins, including:

AKT1 HIF-2 alpha PPAR delta
AMPK alpha 1 IKK alpha PPAR gamma
AMPK alpha 2 IRS1 PTEN
AMPK beta 1 LAMTOR1 Raptor
AMPK beta 2 LKB1 Rheb
Beclin 1 MEK2 RPS6
Cyclin D1 mTOR RSK1
eIF4EBP1 p53 RSK2
GSK3 alpha PDPK1 SIN1
GSK3 beta PGC-1 alpha TSC1
HIF-1 alpha PI3K TSC2
HIF-1 beta PPAR alpha

Get a copy of the mTOR Pathway poster by visiting our literature page.