HIF Prolyl Hydroxylases Products

Description

Under normoxic conditions, the alpha subunits of the transcriptional complex HIF are degraded by proteasomal degradation via the von Hippel-Lindau ubiquitination complex. The HIF Prolyl Hydroxylases (HPHs) are four enzymes that are involved in this degradation pathway. They catalyze the hydroxylation of HIF-1 alpha and target it for degradation. Under hypoxic conditions, HIF Prolyl Hydroxylase is inhibited, allowing the HIF complex to form and signal Hypoxia Response Elements. HPHs are sometimes referred to as PHDs.

Bioinformatics

Product By Gene ID	54583
Alternate Names	C1orf12HPH2 EC 1.14.11 EC 1.14.11.- ECYT3 egl nine homolog 1 (C. elegans) egl nine homolog 1 egl nine-like protein 1 HIF prolyl hydroxylase 2 HIF-PH2 HIFPH2EGL nine (C.elegans) homolog 1 HIF-prolyl hydroxylase 2 HPH-2 Hypoxia-inducible factor prolyl hydroxylase 2 PHD2SM20 Prolyl hydroxylase domain-containing protein 2 SM-20 zinc finger MYND domain-containing protein 6 ZMYND6DKFZp761F179

Research Areas for HIF Prolyl Hydroxylases

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Cancer
Hypoxia

Related HIF Prolyl Hydroxylases Blog Posts

Check out the latest blog posts on HIF Prolyl Hydroxylases.

HIF Prolyl Hydroxylase 1: A Key Regulator of HIF1A Levels Hypoxia inducible factors (HIFs) are transcription factors that regulate the cellular response to decreases in oxygen levels. Under conditions of hypoxia HIFs activate the transcription of a diverse range of genes, resulting in increased oxygen delive...    Read more.

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