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Von Willebrand Disease: Disease Bioinformatics

Von Willebrand Disease is a genetic bleeding disorder. The disease occurs when a blood clotting protein, called the von Willebrand Factor, is defected or absent from an individual. This means that individuals with von Willebrand Disease take longer to stop bleeding and form blood clots. The intensity of symptoms vary between individuals, though the most common symptom of von Willebrand Disease is abnormal bleeding. Other common symptoms include frequent nosebleeds, bleeding from gums, easy bruising, and excessive or uncontrolled bleeding. Von Willebrand Disease often has an autosomal dominant inheritance pattern, but the more severe forms are autosomal recessive. Most individuals with von Willebrand Disease have mild symptoms, so diagnosis of the disease can be difficult. Doctors often take blood tests measuring the levels of von Willebrand factor and the ability of the protein to clot. A variety of treatment options are available depending on the severity of the disease in each individual.

Von Willebrand Disease Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Von Willebrand Disease below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 2184 products for the study of Von Willebrand Disease that can be applied to Flow Cytometry, Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

Immunocytochemistry/Immunofluorescence: Von Willebrand Factor Antibody [NB600-586]Immunohistochemistry-Paraffin: Von Willebrand Factor Antibody [NB600-586] - Staining of formalin-fixed, paraffin-embedded Human Kidney sections with 1:2,000 Rabbit Anti-von Willebrand Factor.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

2 Publications
Western Blot: Factor VIII Antibody [NB100-91761] - Lane1:HepG2 whole cell lysate. Lane2:Mouse liver tissue lysate.Lane3:Rat liver tissue lysate.Immunocytochemistry/Immunofluorescence: Factor VIII Antibody [NB100-91761] - Factor VIII antibody was tested 1:50 in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

2 Publications
Western blot shows lysates of HUVEC human umbilical vein endothelial cells and HepG2 human hepatocellular carcinoma cell line. PVDF membrane was probed with 1:1000 dilution of Rabbit Anti-Human Serpin E1/PAI‑1 Monoclonal Antibody (Catalog # MAB17861) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of HUVEC human umbilical vein endothelial cells, loaded at 0.2 mg/mL. A specific band was detected for Serpin E1/PAI‑1 at approximately 55 kDa (as indicated) using 1:100 dilution of Rabbit Anti-Human Serpin E1/PAI‑1 Monoclonal Antibody (Catalog # MAB17861). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.        Non-specific interaction with the 230 kDa Simple Western standard may be seen with this antibody.

Species Human
Applications WB, Simple Western

Immunohistochemistry-Paraffin: Tenascin C Antibody (4C8MS) [NB110-68136] - Immunohistochemical analysis of Tenascin C on mouse bone and tendon using NB110-68136.Flow Cytometry: Tenascin C Antibody (4C8MS) [NB110-68136] - Intracellular flow cytometric staining of 1 x 10^6 MCF-7 cells using Tenascin C antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

16 Publications
Flow Cytometry: CD31/PECAM1 Antibody (MEC 7.46) [NB100-1642] - CD31/PECAM1 (MEC 7.46) antibody was tested at 1:250 in WEHI-3 cells with DyLight 488 (green) alongside a matched isotype control (black).

Rat Monoclonal
Species Mouse
Applications Flow, ICC/IF, IHC

16 Publications
Western Blot: RNF130 Antibody [NBP1-81858] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4Immunocytochemistry/Immunofluorescence: RNF130 Antibody [NBP1-81858] - Staining of human cell line U-2 OS shows positivity in nucleus & cytoplasm.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC


Goat Polyclonal
Species Human
Applications WB, ChIP, ELISA

10 Publications
Western Blot: Plasminogen Antibody [NB600-930] - Lane 1: Plasminogen. Lane 2: None. Load: 50 ng per lane. Primary antibody: Plasminogen primary antibody at 1:1,000 overnight at 4C. Secondary antibody: Peroxidase goat secondary antibody at 1:40,000 for 60 min at RT. Blocking: incubated with blocking buffer for 30 min at RT. Predicted/Observed size: 91 kDa, 91 kDa for Plasminogen. Other band(s): None.Western Blot: Plasminogen Antibody [NB600-930] - Detection of Plasminogen under reducing (R) and non-reducing (NR) conditions. Reduced samples of purified target proteins contained 4% BME and were boiled for 5 minutes. Samples of 1ug of protein per lane were run by SDS-PAGE. Protein was transferred to nitrocellulose and probed with 1:3000 dilution of primary antibody. Detection shown was using Dylight 649 conjugated Donkey anti goat 1 hr RT.

Goat Polyclonal
Species Human, Bacteria
Applications WB, ELISA

     2 Reviews

6 Publications
Other PRH2 Recombinant Protein

Species Human
Applications WB, ELISA, PA

Related Genes

Von Willebrand Disease has been researched against:

Alternate Names

Von Willebrand Disease is also known as Angiohemophilia, Constitutional Thrombopathy, Pseudohaemophilia, Pseudohemophilia, Pseudohemophilia Type B.