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Von Willebrand Disease: Disease Bioinformatics

Von Willebrand Disease is a genetic bleeding disorder. The disease occurs when a blood clotting protein, called the von Willebrand Factor, is defected or absent from an individual. This means that individuals with von Willebrand Disease take longer to stop bleeding and form blood clots. The intensity of symptoms vary between individuals, though the most common symptom of von Willebrand Disease is abnormal bleeding. Other common symptoms include frequent nosebleeds, bleeding from gums, easy bruising, and excessive or uncontrolled bleeding. Von Willebrand Disease often has an autosomal dominant inheritance pattern, but the more severe forms are autosomal recessive. Most individuals with von Willebrand Disease have mild symptoms, so diagnosis of the disease can be difficult. Doctors often take blood tests measuring the levels of von Willebrand factor and the ability of the protein to clot. A variety of treatment options are available depending on the severity of the disease in each individual.

Von Willebrand Disease Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Von Willebrand Disease below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 1985 products for the study of Von Willebrand Disease that can be applied to Chromatin Immunoprecipitation, Western Blot, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB600-586
Immunocytochemistry/Immunofluorescence: Von Willebrand Factor Antibody [NB600-586]Immunohistochemistry-Paraffin: Von Willebrand Factor Antibody [NB600-586] - Staining of formalin-fixed, paraffin-embedded Human Kidney sections with 1:2,000 Rabbit Anti-von Willebrand Factor.

Rabbit Polyclonal
Species Human
Applications ICC/IF, IHC, IHC-P

     2 Reviews

2 Publications
AF4245

Sheep Polyclonal
Species Human
Applications WB, IP

NB100-91761
Western Blot: Factor VIII Antibody [NB100-91761] - WB detection of Factor VIII protein in extracts from human umbilical vein endothelial cells (HUVECs). Immunocytochemistry/Immunofluorescence: Factor VIII Antibody [NB100-91761] - Factor VIII antibody was tested 1:50 in HeLa cells with Dylight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Image objective 40x.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

2 Publications
NBP1-58268
Western Blot: Coagulation Factor II/Thrombin Antibody [NBP1-58268] - 721_B tissue lysate at a concentration of 1ug/ml.Immunohistochemistry: Coagulation Factor II/Thrombin Antibody [NBP1-58268] - Analysis of human liver after heat-induced Antigen retrieval. Antibody concentration 5 ug/ml.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

NBP1-19773
Western Blot: Serpin E1/PAI-1 Antibody [NBP1-19773] -  Extracts from Jurkat cells.Immunocytochemistry/Immunofluorescence: Serpin E1/PAI-1 Antibody [NBP1-19773] -  PAI1/Serpine1 antibody was tested in Hela cells with DyLight 488 (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     2 Reviews

9 Publications
NBP2-20648
Western Blot: t-Plasminogen Activator/tPA Antibody [NBP2-20648] -  tPA antibody detects PLAT protein by Western blot analysis. A. 30 ug PC-12 whole cell lysate/extract 7.5 % SDS-PAGE  tPA antibody dilution: 1:1000 (Rat)Immunohistochemistry-Paraffin: t-Plasminogen Activator/tPA Antibody [NBP2-20648] -  Paraffin-embedded colon carcinoma. tPA antibody dilution: 1:250.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ELISA, IHC

1 Publication
NB110-68136
Flow (Intracellular): Tenascin C Antibody (4C8MS) [NB110-68136] - Figure A: An intracellular stain was performed on U87MG Cells with Tenascin C (4C8MS) antibody NB110-68136 (blue) and a matched isotype control NBP1-97005 (orange). Cells were fixed with 4% paraformaldehyde, following fixation, cells were permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody [F0101B, R&D Systems].Figure B: U87MG Cells were either untreated (orange) or treated with 3uM Monensin (blue). An intracellular stain was performed with Tenascin C (4C8MS) antibody NB110-68136. Cells were fixed with 4% paraformaldehyde, following fixation, cells were permeabilized with 0.1% saponin. Cells were incubated in an antibody dilution of 1 ug/mL for 30 minutes at room temperature, followed by mouse F(ab)2 IgG (H+L) APC-conjugated secondary antibody [F0101B, R&D Systems].Immunohistochemistry-Paraffin: Tenascin C Antibody (4C8MS) [NB110-68136] - IHC analysis of a formalin fixed paraffin embedded tissue section of mouse bone-tendon using Tenascin C antibody (clone 4C8MS) at 1:25 dilution. The signal was detected using HRP-DAB detection method which followed counterstaining using hematoxylin. The antibody generated a very specific cytoplasmic, membrane and extra-cellular signal in tendon fibroblasts, osteoblasts, osteoclasts, and some bone marrow cells. The mineralized areas were largely negative for the staining.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

     1 Review

17 Publications
NB100-1642
Immunocytochemistry/Immunofluorescence: CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - MS1 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100.  The cells were incubated with anti-CD31/PECAM-1 (MEC 7.46) at 5.0 ug/ml overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution.  Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution.  Nuclei were counterstained with DAPI (Blue).  Cells were imaged using a 40X objective.Flow (Cell Surface): CD31/PECAM-1 Antibody (MEC 7.46) [NB100-1642] - A surface stain was performed on MS-1 Cells with CD31 (MEC 7.46) antibody NB100-1642(blue) and a matched isotype control (orange). Cells were incubated in an antibody dilution of 2.5 ug/mL for 20 minutes at room temperature, followed by rat F(ab)2 IgG (H+L) APC-conjugated secondary antibody (F0113, R&D Systems).

Rat Monoclonal
Species Mouse
Applications Flow, ICC/IF, IHC

18 Publications
NBP1-81858
Western Blot: RNF130 Antibody [NBP1-81858] - Lane 1: Marker  [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.  Lane 2: Human cell line RT-478Immunohistochemistry-Paraffin: RNF130 Antibody [NBP1-81858] - Staining of human kidney shows strong cytoplasmic positivity in cells in tubules.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

NBP1-91258
Western Blot: Fibronectin Antibody [NBP1-91258] - WB analysis of Fibronectin in NIH 3T3 cell lysate.Immunocytochemistry/Immunofluorescence: Fibronectin Antibody [NBP1-91258] - NIH-3T3 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-Fibronectin at 2 ug/ml overnight at 4C and detected with an anti-rabbit Dylight 488 (Green) at a 1:500 dilution. Alpha tubulin (DM1A) NB100-690 was used as a co-stain at a 1:1000 dilution and detected with an anti-mouse Dylight 550 (Red) at a 1:500 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Rabbit Polyclonal
Species Human, Mouse, Bovine
Applications WB, Simple Western, ICC/IF

     5 Reviews

7 Publications
NB110-41083

Goat Polyclonal
Species Human
Applications WB, ChIP, ELISA

10 Publications
NB600-930
Western Blot: Plasminogen Antibody [NB600-930] - Lane 1: Plasminogen. Lane 2: None. Load: 50 ng per lane. Primary antibody: Plasminogen primary antibody at 1:1,000 overnight at 4C. Secondary antibody: Peroxidase goat secondary antibody at 1:40,000 for 60 min at RT. Blocking: incubated with blocking buffer for 30 min at RT. Predicted/Observed size: 91 kDa, 91 kDa for Plasminogen. Other band(s): None.Western Blot: Plasminogen Antibody [NB600-930] - Detection of Plasminogen under reducing (R) and non-reducing (NR) conditions. Reduced samples of purified target proteins contained 4% BME and were boiled for 5 minutes. Samples of 1ug of protein per lane were run by SDS-PAGE. Protein was transferred to nitrocellulose and probed with 1:3000 dilution of primary antibody. Detection shown was using Dylight 649 conjugated Donkey anti goat 1 hr RT.

Goat Polyclonal
Species Human, Bacteria
Applications WB, ELISA

     2 Reviews

7 Publications
NBP2-42213
Western Blot: Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [NBP2-42213] - Western blot analysis of Thrombomodulin/BDCA-3  [6C8.2F9] in mouse heart lysate at 5 ug/ml.Immunohistochemistry-Paraffin: Thrombomodulin/BDCA-3 Antibody (6C8.2F9) [NBP2-42213] - IHC analysis of a formalin fixed paraffin embedded tissue section of human placenta using Thrombomodulin/BDCA-3 antibody (clone 6C8.2F9) at 15 ug/ml concentration. The antibody generated specific staining in the endothelial cells of placental blood vessels while all other cell types including RBCs were found negative for Thrombomodulin.

Mouse Monoclonal
Species Human, Mouse
Applications WB, Flow, IHC

H00005555-P01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human


Related Genes

Von Willebrand Disease has been researched against:

Alternate Names

Von Willebrand Disease is also known as Angiohemophilia, Constitutional Thrombopathy, Pseudohaemophilia, Pseudohemophilia, Pseudohemophilia Type B.