Rheumatoid arthritis is an autoimmune disease that causes chronic inflammation of the joints which eventually leads to their destruction. In rheumatoid arthritis affected joints, lymphocytes are activated causing cytokines, such as tumor necrosis factor (TNF) and interleukin-1 (IL-1), to be expressed in the inflamed areas. T cells from Rheumatoid arthritis patients recognize cartilage protein and a protein encoded by the bacterium that causes tuberculosis, thus suggesting that mycobacterial infection may trigger Rheumatoid arthritis. The incidence of Rheumatoid arthritis has a negative correlation with thymus function. Patients with Rheumatoid arthritis inevitably experience pain alongside the swelling and tenderness associated with rheumatoid joint inflammation. IL-1 and TNF strongly induce the production of PGE2, leukotrienes and platelet-activating factor, which are involved in the pain mechanism. Tumor necrosis factor (TNF) is a cytokine produced by macrophages that causes the inflammation associated with Rheumatoid arthritis. Medications currently available to combat Rheumatoid arthritis function by binding TNF and preventing it from functioning.
Rheumatoid Arthritis Bioinformatics Tool
Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Rheumatoid Arthritis below!
For more information on how to use Laverne, please read the How to Guide.
We have 4129 products for the study of Rheumatoid Arthritis that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.
Rheumatoid Arthritis is also known as Arthritis Rheumatoid, Arthritis, Rheumatoid, Atrophic Arthritis, Chronic Rheumatic Arthritis, Rheumatic Gout.
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