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Pelizaeus-merzbacher Disease: Disease Bioinformatics

Research of Pelizaeus-merzbacher Disease has been linked to Diffuse Cerebral Sclerosis Of Schilder, Leukodystrophy, Nervousness, Nystagmus, Paraplegia. The study of Pelizaeus-merzbacher Disease has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Pelizaeus-merzbacher Disease include Myelination, Pathogenesis, Cell Death, Interphase, Reflex. These pathways complement our catalog of research reagents for the study of Pelizaeus-merzbacher Disease including antibodies and ELISA kits against DM20, JIMPY, ABR, ARSA, CTSC.

Pelizaeus-merzbacher Disease Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Pelizaeus-merzbacher Disease below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 667 products for the study of Pelizaeus-merzbacher Disease that can be applied to Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry from our catalog of antibodies and ELISA kits.

NBP1-87781
Western Blot: Myelin PLP Antibody [NBP1-87781] - Analysis in control (vector only transfected HEK293T lysate) and pLP1 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: Myelin PLP Antibody [NBP1-87781] - Staining in human cerebral cortex and pancreas tissues using anti-PLP1 antibody. Corresponding PLP1 RNA-seq data are presented for the same tissues.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

     1 Review

1 Publication
AF5724
Western blot shows lysates of human, mouse, and rat brain tissue. PVDF membrane was probed with 1 µg/mL of Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF5724) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Peroxiredoxin 5  was detected in immersion fixed A549 human lung carcinoma cell line using  Goat Anti-Human/Mouse/Rat Peroxiredoxin 5 Antigen Affinity-purified  Polyclonal Antibody (Catalog # AF5724) at 10 µg/mL for 3  hours at room temperature. Cells were stained using the  NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody  (red; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC

NBP2-27461
Western Blot: PDXP Antibody [NBP2-27461] - 0.1 ug/ml staining of Mouse (A) and Rat (B) Brain lysates (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Immunohistochemistry-Paraffin: PDXP Antibody [NBP2-27461] - 5ug/ml staining of paraffin embedded Human Tonsil. Steamed antigen retrieval with citrate buffer Ph 6, AP-staining.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC, IHC-P

1 Publication
NBP2-35224
SDS-Page: Human PTHLH/PTHrP Protein [NBP2-35224]


Species Human

NBP1-59263
Western Blot: GJC2 Antibody [NBP1-59263] - Antibody Titration: 1 ug/ml Human liver.Immunohistochemistry: GJC2 Antibody [NBP1-59263] - Formalin Fixed Paraffin Embedded Tissue: Human Adult heart Observed Staining: Membrane, some cytoplasm Primary Antibody Concentration: 1:100 Secondary Antibody: Donkey anti-Rabbit-Cy2/3 Secondary Antibody Concentration: 1:200 Magnification: 20X Exposure Time: 0.5 - 2.0 sec Protocol located in Reviews and Data.

Rabbit Polyclonal
Species Human
Applications WB, IHC

NBP2-38445
Western Blot: RNF6 Antibody [NBP2-38445] - Lane 1: Marker  [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.  Lane 2: Negative Control.  Lane 3: Overexpression lysateImmunocytochemistry/Immunofluorescence: RNF6 Antibody [NBP2-38445] - Immunofluorescent staining of human cell line U-2 OS shows localization to nuclear membrane.

Rabbit Polyclonal
Species Human
Applications WB, ICC/IF, IHC

NB600-717
Western Blot: MBP Antibody (12) [NB600-717] - Mouse Brain Tissue lysate probed with Rat anti MBP.

Rat Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

14 Publications
538-MG


Species Rat

     1 Review

14 Publications
NB110-59086
Immunohistochemistry: PMP22 Antibody (Hu1) [NB110-59086] - Staining of PMP22 (brown) in dorsal root ganglion and spinal roots in 20 week fetal spinal cord preparation from rhesus monkey.

Mouse Monoclonal
Species Human, Primate, Bovine (Negative)
Applications WB, IHC, IHC-P

1 Publication
NBP1-81021
Immunocytochemistry/Immunofluorescence: Myt1 Antibody [NBP1-81021] - Immunofluorescent staining of human cell line SH-SY5Y shows localization to nucleoplasm & cytosol.Immunohistochemistry-Paraffin: Myt1 Antibody [NBP1-81021] - Staining of human cerebellum shows moderate nuclear positivity in cells in granular layer.

Rabbit Polyclonal
Species Human, Mouse
Applications ICC/IF, IHC, IHC-P

3 Publications
NBP2-02275
Western Blot: PKMYT1 Antibody (5E1) [NBP2-02275] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY PKMYT1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-PKMYT1.Immunocytochemistry/Immunofluorescence: PKMYT1 Antibody (5E1) [NBP2-02275] - Staining of COS7 cells transiently transfected by pCMV6-ENTRY PKMYT1.

Mouse Monoclonal
Species Human, Monkey
Applications WB, Flow, ICC/IF

MAB19101
Western Blot: EMAP-II/AIMP1 Antibody (959507) [MAB19101] - Detection of Human, Mouse, and Rat EMAP-II by Western Blot. Western blot shows lysates of Daudi, SK-OV-3, M1, Neuro2A and Rat-2 cell lysates. PVDF membrane was probed with Mouse Anti-Human EMAP-II Monoclonal Antibody (Catalog # MAB19101) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF018). A specific band was detected for EMAP-II at approximately 38 kDa (as indicated). This experiment was conducted under reducing conditions

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, IHC, ICC

AF1034
Western blot shows lysates of mouse liver tissue and mouse spleen tissue. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Mouse Cathepsin C/DPPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1034) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of mouse spleen tissue, loaded at 0.2 mg/mL. A specific band was detected for Cathepsin C/DPPI at approximately 35 kDa (as indicated) using 2.5 µg/mL of Goat Anti-Mouse Cathepsin C/DPPI Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1034) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, Simple Western, IHC

     1 Review

9 Publications
NBP1-88573
Western Blot: PRG2 Antibody [NBP1-88573] - Analysis in control (vector only transfected HEK293T lysate) and pRG2 over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: PRG2 Antibody [NBP1-88573] - Staining of human skeletal muscle shows no cytoplasmic positivity as expected.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
AF2307

Goat Polyclonal
Species Human
Applications WB, ELISA(Cap), ELISA(Det)

5 Publications
NBP1-77397
Western Blot: HSP60 Antibody [NBP1-77397] - Western blot analysis of extracts from HeLa and COS cells using NBP1-77397 Hsp60 antibody at 1:1000Immunocytochemistry/Immunofluorescence: HSP60 Antibody [NBP1-77397] - Confocal immunofluorescent analysis of HeLa cells using Hsp60 antibody (NBP1-77397, 1:100). An Alexa Fluor 488-conjugated Goat to rabbit IgG was used as secondary antibody (green, A). Actin filaments were labeled with Alexa Fluor 568 phalloidin (red, B). DAPI was used to stain the cell nuclei (blue, C).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, Flow

     4 Reviews

NBP1-30981
Western Blot: ABR Antibody [NBP1-30981] - Sample (30ug whole cell lysate) A:A431, 7.5% SDS PAGE, antibody diluted at 1:1000.Immunocytochemistry/Immunofluorescence: ABR Antibody [NBP1-30981] - Analysis of paraformaldehyde-fixed A431, using  ABR(NBP1-30981) antibody at 1:500 dilution.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF


Related Genes

Pelizaeus-merzbacher Disease has been researched against:

Related PTMs

Pelizaeus-merzbacher Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Pelizaeus-merzbacher Disease is also known as pelizaeus-merzbacher disease, spastic paraplegia 2, hereditary x-linked recessive spastic paraplegia, cockayne-pelizaeus-merzbacher disease, pelizaeus merzbacher brain sclerosis, plp1-related disorders, spg2, pmd, x linked recessive hereditary spastic paraplegia, spastic paraplegia 2, x-linked (disorder), pelizaeus-merzbacher disease (disorder), sclerosis, brain, pelizaeus-merzbacher, anophthalmia and pulmonary hypoplasia, spastic paraplegia type 2, spastic paraplegia-2, spastic paraplegia, leukodystrophies, leukodystrophy, spg 2, sppx2, pmds, hsp2.