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Inflammation: Disease Bioinformatics

In the most general terms, inflammation is a biological response produced by the body’s immune system to protect itself from potentially harmful substances. There are two types of inflammation: acute inflammation and chronic inflammation. Acute inflammation is the rapid-onset type of inflammation that produces symptoms for only a few days. Chronic inflammation is a long-term type of inflammation that may be caused by the body’s failure to eliminate the cause of an acute inflammatory response or by an autoimmune response. On the cellular level, inflammation is mediated by a variety of cell types, including neutrophils, basophils, eosinophils, macrophages, monocytes, lymphocytes, fibroblasts and plasma cells. There is a complex series of proteins that mediate the inflammatory response. Cytokines are signaling proteins produced by various cells for use in cellular communication in order to regulate inflammation. Interleukin 1 (IL-1) and Interleukin 6 (IL-6) are released by macrophages and work with TNF-alpha to induce inflammation at the onset of infection. Interleukin 8 (IL-8) is a chemotactic factor that recruits neutrophils from the blood to sites of infection in order to initiate the inflammatory response. Chemokines, small proteins that are also involved in the inflammatory response, are a type of cytokine that attract leukocytes to infection sites by acting as chemoattractants. Chemokines interact with the targeted leukocyte via GPCRs. This interaction causes two effects: first, the leukocyte’s adhesive properties change allowing movement from blood to tissue and secondly, the leukocyte’s movement to the center of infection is driven via a chemokine gradient.

Inflammation Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Inflammation below! For more information on how to use Laverne, please read the How to Guide.

Vizit™, under license from BioVista Inc.

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We have 5283 products for the study of Inflammation that can be applied to Chromatin Immunoprecipitation, Chromatin Immunoprecipitation (ChIP), Flow Cytometry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

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