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Impaired Cognition: Disease Bioinformatics

Research of Impaired Cognition has been linked to Cognition Disorders, Dementia, Alzheimer's Disease, Mild Cognitive Disorder, Depressive Disorder. The study of Impaired Cognition has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Impaired Cognition include Cognition, Aging, Pathogenesis, Short-term Memory, Cell Death. These pathways complement our catalog of research reagents for the study of Impaired Cognition including antibodies and ELISA kits against ACHE, APOE, APP, BCHE, BDNF.

Impaired Cognition Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Impaired Cognition below! For more information on how to use Laverne, please read the How to Guide.
Vizit™, under license from BioVista Inc.

Top Research Reagents

We have 2052 products for the study of Impaired Cognition that can be applied to Flow Cytometry, Chromatin Immunoprecipitation, Western Blot, Immunocytochemistry/Immunofluorescence, Chromatin Immunoprecipitation (ChIP), Immunohistochemistry from our catalog of antibodies and ELISA kits.

NB110-60531
Western Blot: ApoE Antibody (WUE-4) [NB110-60531] - 50 ug protein per lane for liver lysate and 0.5 ul of plasma at 9% SDS. Samples are loaded onto the gel as the following order: human liver lysate, mouse liver lysate, rat liver lysate, human plasma, and mouse plasma. Image from confirmed customer review.Immunocytochemistry/Immunofluorescence: Apolipoprotein E/ApoE Antibody (WUE-4) [NB110-60531] - HepG2 cells were fixed for 10 minutes using 10% formalin and then permeabilized for 5 minutes using 1X TBS + 0.5% Triton-X100. The cells were incubated with anti-ApoE (WUE-4) [NB110-60531] at a 1:200 dilution overnight at 4C and detected with an anti-mouse Dylight 488 (Green) at a 1:500 dilution. Actin was detected with Phalloidin 568 (Red) at a 1:200 dilution. Nuclei were counterstained with DAPI (Blue). Cells were imaged using a 40X objective.

Mouse Monoclonal
Species Human, Mouse, Rat (Negative)
Applications WB, ELISA, Flow

     2 Reviews

9 Publications
NBP2-13075
Western Blot: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Western blot analysis in cell lysates from HEK-APP SWE/BACE1 cells probed with an antibody against the C-terminus of APP (Lanes 1 and 2) and beta Amyloid  (MOAB-2, Lanes 3 and 4).  Beta Amyloid (MOAB-2) does not detect APP (from PMID: 22423893).Immunocytochemistry/Immunofluorescence: beta Amyloid Antibody (MOAB-2) [NBP2-13075] - Immunofluorescent detection of beta Amyloid with MOAB-2 in the subiculim of 1-, 2- and 4- month old 5xFAD mice.  Scale bar 20 um (from PMID: 22423893).

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

9 Publications
NBP2-25162
Western Blot: Tau Antibody (2E9) [NBP2-25162] - Blots of crude rat brain extract, revealing, as expected, multiple bands in the range 48-67kDa.Immunocytochemistry/Immunofluorescence: Tau Antibody (2E9) [NBP2-25162] - E18 primary rat hippocampal neurons (from Neuromics) were fixed and immunostained with NBP2-25162 (green), chicken antibody to alpha Internexin (NBP1-05208, red) and for DNA (blue). NBP2-25162 stains the neuronal perikarya and processes strongly, and does not stain non neuronal cells in these cultures. The alpha Internexin antibody stains intermediate or 10nm filament bundles in the cytoplasm of these cells.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF

215-GM/CF
1 μg/lane of Recombinant Human GM-CSF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 14 kDa.Recombinant Human GM-CSF (Catalog # 215-IL/CF) stimulates cell proliferation of the TF-1 human erythroleukemic cell line. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human

181 Publications
NBP2-42388
Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in human cell line A-431.Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining of human lymph node shows absence of immunoreactivity in lymphoid tissue (negative control).

Mouse Monoclonal
Species Human
Applications WB, IHC, IHC-P

NBP2-22449
Western Blot: Acetylcholinesterase/ACHE Antibody (ZR3) [NBP2-22449] - Western blot analysis was performed on whole cell extracts (30 ug lysate) of Mouse Brain (lane 1), HeLa (lane 2), SK-N-SH (lane 3) and U-87 MG (lane 4).Immunocytochemistry/Immunofluorescence: Acetylcholinesterase/ACHE Antibody (ZR3) [NBP2-22449] - Analysis of Acetylcholinesterase using Acetylcholinesterase Monoclonal antibody (ZR3) shows staining in U251 glioma cells. Acetylcholinesterase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Acetylcholinesterase at a dilution of 1:20 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

AF9024
  Western  blot shows lysates of mouse heart tissue and mouse liver tissue. PVDF  membrane was probed with 1 µg/mL of Goat Anti-Mouse/Rat  Butyrylcholinesterase/BCHE Polyclonal Antibody (Catalog # AF9024) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=  Butyrylcholinesterase/BCHE  was detected in perfusion fixed frozen sections of mouse brain using Goat  Anti-Mouse/Rat Butyrylcholinesterase/BCHE Antigen Affinity-purified  Polyclonal Antibody <br>(Catalog # AF9024) at 5 µg/mL  overnight at 4 °C. Tissue was stained using the Anti-Goat  HRP-DAB Cell & Tissue Staining Kit   (brown; Catalog # <a class=

Goat Polyclonal
Species Mouse, Rat
Applications WB, IHC

248-BD/CF
1 μg/lane of Recombinant Human BDNF was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 13 kDa.Recombinant Human BDNF (Catalog #<br>248‑BD/CF) stimulates cell proliferation in the BaF mouse pro-B cell line transfected with TrkB. The ED<sub>50</sub> for this effect is 0.2-2 ng/mL.


Species Human, Mouse, Rat

77 Publications
NB300-749
Western Blot: Presenilin-1 Antibody (APS 11) [NB300-749] - Analysis of 25 ug of SH-SY5Y (lane 1), human brain (lane 2) and mouse brain (lane 3).Immunocytochemistry/Immunofluorescence: Presenilin-1 Antibody (APS 11) [NB300-749] - Mouse fibroblasts.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, ICC/IF

     1 Review

1 Publication
NBP2-34260
Immunohistochemistry-Paraffin: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260] - Formalin-fixed, paraffin-embedded human pancreas stained with insulin Monoclonal Antibody (E2-E3)SDS-Page: Insulin Antibody (E2-E3 (same as INS04)) [NBP2-34260]

Mouse Monoclonal
Species Human, Mouse, Porcine
Applications WB, Flow, ICC/IF

     4 Reviews

AF2180
    Simple  Western lane view shows lysates of HEL 92.1.7 human erythroleukemic  cell line and human liver tissue, loaded at 0.2 mg/mL. A specific  band was detected for Carbonic Anhydrase I/CA1 at approximately  38 kDa (as indicated) using 5 µg/mL of Goat Anti-Human  Carbonic Anhydrase I/CA1 Antigen Affinity-purified Polyclonal  Antibody (Catalog # AF2180) followed by 1:50 dilution of HRP-conjugated  Anti-Goat IgG Secondary Antibody (Catalog # <a class=    Western  blot shows lysates of HEL 92.1.7 human erythroleukemic cell line,  human liver tissue, and human colon tissue. PVDF membrane was probed with  0.1 µg/mL of Goat Anti-Human Carbonic Anhydrase I/CA1  Antigen Affinity-purified Polyclonal Antibody (Catalog # AF2180) followed by  HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=

Goat Polyclonal
Species Human
Applications WB, Simple Western, IP

375-TL/CF


Species Human

24 Publications
NBP1-90306
Western Blot: alpha Sarcoglycan Antibody [NBP1-90306] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).Immunohistochemistry-Paraffin: alpha Sarcoglycan Antibody [NBP1-90306] - Staining of human heart muscle shows distinct positivity of intercalated discs in myocytes.

Rabbit Polyclonal
Species Human
Applications WB, IHC, IHC-P

1 Publication
210-TA/CF
1 µg/lane of Recombinant Human TNF-alpha  was resolved by SDS-PAGE with silver staining, under reducing (R) conditions, showing a band at 17 kDa.Recombinant Human TNF-alpha  (Catalog # 210‑TA/CF) induces cytotoxicity in the L-929 mouse fibroblast cell line in the presence of the metabolic inhibitor actinomycin D. The ED<sub>50</sub> for this effect is 25‑100 pg/mL.


Species Human

418 Publications
NBP1-30052
Western Blot: Choline Acetyltransferase/ChAT Antibody [NBP1-30052] - Rat brain lysate showing specific immunolabeling of the ~70k ChAT.Immunohistochemistry-Paraffin: Choline Acetyltransferase/ChAT Antibody [NBP1-30052] - Rat brainstem showing specific labeling using the anti-ChAT antibody. Image courtesy of Dr. Robert Sloviter, University of Arizona.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC

6 Publications
NB100-616
Western Blot: KAT3B/p300 Antibody (RW105) [NB100-616] - p300 detected in a HeLa nuclear extract using NB 100-616 (1:250).  ECL: 20 minute exposure.Flow (Intracellular): KAT3B/p300 Antibody (RW105) [NB100-616] - An intracellular stain was performed on RAW 246.7 cells with KAT3B/p300 antibody (RW105) NB100-616PE (blue) and a matched isotype control NBP2-27287PE (orange). Cells were fixed with 4% PFA and then permeablized with 0.1% saponin. Cells were incubated in an antibody dilution of 2 ug/mL for 30 minutes at room temperature. Both antibodies were conjugated to Phycoerythrin.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ChIP, EM

8 Publications
NBP2-02023
Western Blot: RUNX1T1/ETO Antibody (1H1) [NBP2-02023] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1/ETO (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1/ETO.Immunocytochemistry/Immunofluorescence: RUNX1T1/ETO Antibody (1H1) [NBP2-02023] Staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1/ETO.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF

H00001109-M01
Western Blot: Aldo-keto Reductase 1C4/AKR1C4 Antibody (2C11) [H00001109-M01] - AKR1C4 monoclonal antibody (M01), clone 2C11 Analysis of AKR1C4 expression in MCF-7.Immunocytochemistry/Immunofluorescence: Aldo-keto Reductase 1C4/AKR1C4 Antibody (2C11) [H00001109-M01] - Analysis of monoclonal antibody to AKR1C4 on HepG2 cell. Antibody concentration 15 ug/ml.

Mouse Monoclonal
Species Human
Applications WB, ELISA, ICC/IF

2 Publications
NB100-56703
Western Blot: Huntingtin Antibody (1A771) [NB100-56703] - Analysis of Htt in four different lymphoblast HD cell lines extracts each expressing ~65 (mutant) and ~20 (normal) CAG repeats. Lanes 1-4. A, HTT mAb clone 1A771. B. An Htt antibody recognizing both normal and mutant Htt (B). this antibody. In contrast, the other antibody recognized both the expanded (~65) and normal (~20) repeat Htt forms.

Mouse Monoclonal
Species Human, Mouse
Applications WB, IHC, IHC-Fr