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Hirschsprung Disease: Disease Bioinformatics

Research of Hirschsprung Disease has been linked to Megacolon, Constipation, Intestinal Obstruction, Nervousness, Enterocolitis. The study of Hirschsprung Disease has been mentioned in research publications which can be found using our bioinformatics tool below. Researched pathways related to Hirschsprung Disease include Pathogenesis, Innervation, Reflex, Defecation, Peristalsis. These pathways complement our catalog of research reagents for the study of Hirschsprung Disease including antibodies and ELISA kits against ENDOTHELIN-B RECEPTOR, ACHE, EDN3, EDNRB, ENO2.

Hirschsprung Disease Bioinformatics Tool

Laverne is a handy bioinformatics tool to help facilitate scientific exploration of related genes, diseases and pathways based on co-citations. Explore more on Hirschsprung Disease below! For more information on how to use Laverne, please read the How to Guide.
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Top Research Reagents

We have 1047 products for the study of Hirschsprung Disease that can be applied to Western Blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry, Immunohistochemistry from our catalog of antibodies and ELISA kits.

AF482
Ret was detected in perfusion fixed frozen sections of mouse spinal cord using Goat Anti-Mouse Ret Antigen Affinity-purified Polyclonal Antibody (Catalog # AF482) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # <a class=

Goat Polyclonal
Species Mouse
Applications WB, IHC

19 Publications
AF4496
Western blot shows lysates of HEK293 human embryonic kidney cell line, A172 human glioblastoma cell line, and Raji human Burkitt's lymphoma cell line. PVDF membrane was probed with 1 µg/mL of Sheep Anti-Human EDNRB/Endothelin R Type B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4496) followed by HRP-conjugated Anti-Sheep IgG Secondary Antibody (Catalog # <A class=NoLineLink href=EDNRB/Endothelin R Type B was detected in immersion fixed A172 human glioblastoma cell line using 10 µg/mL Sheep Anti-Human EDNRB/Endothelin R Type B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4496) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # <A class=NoLineLink href=

Sheep Polyclonal
Species Human
Applications WB, Flow, CyTOF-ready

NBP2-22449
Western Blot: Acetylcholinesterase/ACHE Antibody (ZR3) [NBP2-22449] - Western blot analysis was performed on whole cell extracts (30 ug lysate) of Mouse Brain (lane 1), HeLa (lane 2), SK-N-SH (lane 3) and U-87 MG (lane 4).Immunocytochemistry/Immunofluorescence: Acetylcholinesterase/ACHE Antibody (ZR3) [NBP2-22449] - Analysis of Acetylcholinesterase using Acetylcholinesterase Monoclonal antibody (ZR3) shows staining in U251 glioma cells. Acetylcholinesterase staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing Acetylcholinesterase at a dilution of 1:20 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, ELISA, Flow

NBP2-20486
Western Blot: SS18L1 Antibody [NBP2-20486] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 10% SDS PAGE gel, diluted at 1:1000.Immunocytochemistry/Immunofluorescence: SS18L1 Antibody [NBP2-20486] - Immunofluorescence analysis of paraformaldehyde-fixed A431, using antibody at 1:500 dilution.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, ICC/IF, IHC

MAB5579
    Endothelin‑3  was detected in immersion fixed LNCaP human prostate cancer cell line using  Mouse Anti-Human Endothelin‑3 Monoclonal Antibody (Catalog #  MAB5579) at 25 µg/mL for 3 hours at room temperature.  Cells were stained using the NorthernLights™ 557-conjugated  Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=

Mouse Monoclonal
Species Human
Applications ICC

NB100-56703
Western Blot: Huntingtin Antibody (1A771) [NB100-56703] - Analysis of Htt in four different lymphoblast HD cell lines extracts each expressing ~65 (mutant) and ~20 (normal) CAG repeats. Lanes 1-4. A, HTT mAb clone 1A771. B. An Htt antibody recognizing both normal and mutant Htt (B). this antibody. In contrast, the other antibody recognized both the expanded (~65) and normal (~20) repeat Htt forms.

Mouse Monoclonal
Species Human, Mouse
Applications WB, IHC, IHC-Fr

MAB2864
SOX10 was detected in immersion fixed BG01V human embryonic stem cells differentiated to neural crest stem cells using Mouse Anti-Human/Rat SOX10 Monoclonal Antibody (Catalog # MAB2864) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=        SOX10  was detected in immersion fixed paraffin-embedded sections of human melanoma  tissue using Mouse Anti-Human/Rat SOX10 Monoclonal Antibody (Catalog #  MAB2864) at 5 µg/mL for 1 hour at room temperature  followed by incubation with the Anti-Mouse IgG VisUCyte™  HRP Polymer Antibody (Catalog #  <a class=

Mouse Monoclonal
Species Human, Rat
Applications IHC, ICC

6 Publications
NBP1-82991
Western Blot: ZEB2 Antibody [NBP1-82991] - Analysis in human cell line HELA.Immunohistochemistry-Paraffin: ZEB2 Antibody [NBP1-82991] - Immunohistochemical staining of human cerebral cortex shows moderate nuclear positivity in glial cells.

Rabbit Polyclonal
Species Human, Mouse
Applications WB, IHC, IHC-P

8 Publications
NBP1-05163
Immunocytochemistry/Immunofluorescence: VIP Antibody (2) [NBP1-05163] - Staining in human pancreas tissue. Signal is strong in nerves of exocrine part of pancreas. Dilution: 1:100.Immunohistochemistry-Paraffin: VIP Antibody (2)  - BSA Free [NBP1-05163] - Formalin fixed paraffin-embedded human pancreas tissue. Dilution: 1:100

Mouse Monoclonal
Species Human, Rat, Porcine
Applications WB, ELISA, ICC/IF

AF4940
PHOX2B was detected in immersion fixed IMR-32 human neuroblastoma cell line using Goat Anti-Human PHOX2B Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4940) at 10 µg/mL for 3 hours at room temperature. Cells were stained using the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human, Mouse
Applications ICC

NBP2-13955
Immunohistochemistry-Paraffin: ELL Antibody [NBP2-13955] - Staining of human testis shows moderate nuclear positivity in cells of seminiferus ducts.

Rabbit Polyclonal
Species Human
Applications IHC, IHC-P

NB110-58870
Western Blot: Enolase 2/Neuron-specific Enolase Antibody [NB110-58870] - Western blot analysis of extracts from mouse brain using NSE antibody (NB110-58870, 1:100).Immunocytochemistry/Immunofluorescence: Enolase 2/Neuron-specific Enolase Antibody [NB110-58870] - Confocal immunofluorescent analysis of 3T3 cells using NSE antibody (NB110-58870, 1:5). An Alexa Fluor 488-conjugated Goat to rabbit IgG was used as secondary antibody (green, A). Actin filaments were labeled with Alexa Fluor 568 phalloidin (red, B). DAPI was used to stain the cell nuclei (blue, C).

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC/IF

     2 Reviews

AF477
  Neurturin  was detected in immersion fixed frozen sections of mouse embryo (13 d.p.c.)  using Goat Anti-Human/Mouse Neurturin Antigen Affinity-purified Polyclonal  Antibody (Catalog # AF477) at 15 µg/mL overnight at  4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell  & Tissue Staining Kit  (brown;  Catalog # <a class=

Goat Polyclonal
Species Human, Mouse
Applications WB, IHC, Block

3 Publications
NB300-187
Immunocytochemistry/Immunofluorescence: Substance P Antibody [NB300-187] - Detection of Substance P in rat spinal cord dorsal horn (red fluorescence). DAPI (blue) was used as counter stain.Immunohistochemistry: Substance P Antibody [NB300-187] - Spinal Cord Dorsal Horn (Human).

Guinea Pig Polyclonal
Species Human, Mouse, Rat
Applications ICC/IF, IHC

7 Publications
NBP2-02149
Western Blot: L1CAM Antibody (2A6) [NBP2-02149] Analysis of extracts (35ug) from 9 different cell lines by using anti-L1CAM monoclonal antibody.Immunocytochemistry/Immunofluorescence: L1CAM Antibody (2A6) [NBP2-02149] - Staining of COS7 cells.

Mouse Monoclonal
Species Human, Monkey
Applications WB, Flow, ICC/IF

NB600-1160
Western Blot: UCH-L1/PGP9.5 Antibody (31A3) [NB600-1160] - analysis of UchL1 in 1) human, 2) mouse and 3) rat brain lysate using UchL1 antibody at 1 ug/ml.  goat anti-mouse Ig HRP secondary antibody and ECL substrate solution were used for this test.Immunocytochemistry/Immunofluorescence: UCH-L1/PGP9.5 Antibody (31A3) [NB600-1160] - analysis of PGP9.5 in rat mesenteric artery using anti-PGP9.5 antibody. Image from verified customer review.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ELISA

     1 Review

8 Publications
AF1356
Western blot shows lysates of MO7e human megakaryocytic leukemic cell line, P815 mouse mastocytoma cell line, and MC/9‑2 mouse mast cell line. PVDF membrane was probed with 0.1 µg/mL of Goat Anti-Human/Mouse CD117/c-kit Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1356) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=Simple Western lane view shows lysates of MO7e human megakaryocytic leukemic cell line, P815 mouse mastocytoma cell line and MC/9-2 mouse mast cell line, loaded at 0.2 mg/mL. A specific band was detected for CD117/c-kit at approximately 150-165 kDa (as indicated) using 5 µg/mL of Goat Anti-Human/Mouse CD117/c-kit Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1356) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <A class=NoLineLink href=

Goat Polyclonal
Species Human, Mouse
Applications WB, Simple Western, Flow

     5 Reviews

16 Publications

Related Genes

Hirschsprung Disease has been researched against:

Related PTMs

Hirschsprung Disease has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Hirschsprung Disease is also known as Aganglionic Megacolon, Aganglionosis, Congenital Aganglionic Megacolon, Congenital Megacolon, Hirschsprung Disease 1.