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Cataplexy And Narcolepsy: Disease Bioinformatics

Narcolepsy is a neurological disorder affecting the part of the brain that regulates sleep. Those suffering from narcolepsy can experience excessive daytime sleepiness, hallucinations, and sudden loss of muscle control. A normal sleep cycle is about 100 to 110 minutes, beginning with NREM (non rapid eye movement) sleep and transitioning to REM(rapid eye movement) sleep after 80 to 100 minutes. People with narcolepsy frequently enter REM sleep within a few minutes of falling asleep. Narcolepsy effects both men and women equally and is widespread throughout the world. It mostly begins during a person’s childhood and is lifelong. Diagnosis of the condition can take a long time in most cases more than a year and sometimes as long as several decades because narcolepsy symptoms are often mistakenly linked to other sleep disorders or medical conditions such as depression. The only unique symptom of narcolepsy is cataplexy this happens when you lose the ability to control your muscles. Narcolepsy with cataplexy is estimated to affect about one in every 2,000 people in the USA. When cataplexy is present, narcolepsy is almost always caused by the lack of a brain neurotransmitters called hypocretin. Neurotransmitters are chemicals that neurons produce to communicate with each other. Loss of hypocretin results in an inability to regulate sleep. In cases without cataplexy, the disorder may be caused by a lack of hypocretin or by various other causes. People with narcolepsy can fight off the urge to fall asleep with exercise this will keep your heart rate elevated and more awake during the day.

Top Research Reagents

We have 2447 products for the study of Cataplexy And Narcolepsy that can be applied to Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Western Blot from our catalog of antibodies and ELISA kits.

PNPLA6 Antibody (3D10) - Azide and BSA Free
H00010908-M08
Western Blot: PNPLA6 Antibody (3D10) [H00010908-M08] - Analysis of PNPLA6 expression in transfected 293T cell line by NTE monoclonal antibody (M08), clone 3D10. Lane 1: PNPLA6 transfected lysate (Predicted MW: 146.2 KDa). Lane 2: Non-transfected lysate.Immunohistochemistry-Paraffin: PNPLA6 Antibody (3D10) [H00010908-M08] - Analysis of monoclonal antibody to PNPLA6 on formalin-fixed paraffin-embedded human small Intestine. Antibody concentration 3 ug/ml

Mouse Monoclonal
Species Human
Applications WB, ELISA, IHC

HLA DQB1 Antibody - BSA Free
NBP3-16006
Western Blot: HLA DQB1 Antibody [NBP3-16006] - Western blot analysis of extracts of Raji cells, using HLA DQB1 antibody (NBP3-16006) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s.Immunohistochemistry-Paraffin: HLA DQB1 Antibody [NBP3-16006] - Immunohistochemistry of paraffin-embedded human colon carcinoma using HLA DQB1 antibody (NBP3-16006) at dilution of 1:100 (40x lens).Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6.0 before commencing with IHC staining protocol.

Rabbit Polyclonal
Species Human
Applications WB, ELISA, IHC

HLA DQB2 Antibody - BSA Free
NBP3-17054
Immunocytochemistry/Immunofluorescence: HLA DQB2 Antibody [NBP3-17054] - Analysis in human skin and colon tissues using Anti-HLA-DQB2 antibody. Corresponding HLA-DQB2 RNA-seq data are presented for the same tissues.Immunohistochemistry-Paraffin: HLA DQB2 Antibody [NBP3-17054] - Staining of human skin shows high expression.

Rabbit Polyclonal
Species Human
Applications IHC,  IHC-P

VAChT/SLC18A3 Antibody
NB100-91348
Western Blot: VAChT/SLC18A3 Antibody [NB100-91348] - Rat and mouse tissue lysates. Blocking: 1% LFDM for 30 min at RT; primary antibody: dilution 1:2000 incubated at 4C overnight.Immunohistochemistry-Paraffin: VAChT/SLC18A3 Antibody [NB100-91348] - Rat spinal cord. The animal was perfused at a pressure of 130 mmHg with 300 ml 4% FA before being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min. Blocking: 0.2% LFDM in TBST filtered thru 0.2 um.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, IHC,  IHC-P

2 Publications
POMC Antibody
NB100-1533
Immunohistochemistry: POMC Antibody [NB100-1533] - Representative confocal images of POMC in POMC-transfected WT and Sel1L-/- N2a cells. White arrows point to POMC-containing secretory granules, while yellow arrows point to perinuclear POMC. KDEL marks the ER. Representative data from at least 2 independent experiments are shown. Image collected and cropped by CiteAb from the following publication (jci.org/articles/view/96420), licensed under a CC-BY license.Flow Cytometry: POMC Antibody [NB100-1533] - Flow cytometric analysis of paraformaldehyde fixed A431 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (10 ug/mL) followed by Alexa Fluor 488 secondary antibody (1 ug/mL). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

11 Publications
LIFR alpha Antibody [Unconjugated]
AF-249-NA
Recombinant Human LIF stimulates proliferation in the TF‑1 human erythroleukemic cell line in a dose-dependent manner (orange line). Proliferation elicited by 0.3 ng/mL Recombinant Human LIF is neutralized (green line) by increasing concentrations of Goat Anti-Human LIF R alpha Antigen Affinity-purified Polyclonal Antibody (Catalog # AF-249-NA). The ND<SUB>50</SUB> is typically 6-36 µg/mL.

Goat Polyclonal
Species Human
Applications WB, Neut

16 Publications
Nucleostemin Antibody [Unconjugated]
AF1638
Western blot shows lysates of PC-3 human prostate cancer cell line and SW480 human colorectal adenocarcinoma cell line. PVDF membrane was probed with 0.25 µg/mL of Goat Anti-Human/Mouse/Rat Nucleostemin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1638) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # <a class=Nucleostemin was detected in immersion fixed U2OS human osteosarcoma cell line using 10 µg/mL Goat Anti-Human/Mouse/Rat Nucleostemin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1638) for 3 hours at room temperature. Cells were stained with the NorthernLights™ 557-conjugated Anti-Goat IgG Secondary Antibody (red, upper panel; Catalog # <a class=

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Simple Western, ICC

11 Publications
GM-CSF [Unconjugated]
7954-GM/CF
Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED<sub>50</sub> for this effect is 6-30 pg/mL.


Species Human
Applications BA

3 Publications
Orexin A/Hypocretin-1 Antibody (97505) [Unconjugated]
MAB763
Orexin A/Hypocretin‑1 was detected in immersion fixed paraffin-embedded sections of Mouse Hypothalamus using Mouse Anti-Human/Mouse Orexin A/Hypocretin‑1 Monoclonal Antibody (Catalog # MAB763) at 5 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Mouse IgG Secondary Antibody (red; Catalog # <a class=NoLineLink href=

Mouse Monoclonal
Species Human, Mouse
Applications IHC

21 Publications
LAMC2 Antibody (CL2980) - BSA Free
NBP2-42388
Immunohistochemistry-Paraffin: LAMC2 Antibody (CL2980) [NBP2-42388] - Staining in human fallopian tube and liver tissues. Corresponding LAMC2 RNA-seq data are presented for the same tissues.Western Blot: LAMC2 Antibody (CL2980) [NBP2-42388] - Analysis in A-431 cells transfected with control siRNA, target specific siRNA probe #1 and #2, using Anti-LAMC2 antibody. Remaining relative intensity is presented. Loading control: Anti-GAPDH.

Mouse Monoclonal
Species Human
Applications WB, ICC/IF, IHC

4 Publications
Acetylcholinesterase/ACHE Antibody
NB100-1519
Western Blot: Acetylcholinesterase/ACHE Antibody [NB100-1519] - Staining (0.3ug/ml) of Jurkat (A) and (0.5ug/ml) HepG2 (B) cell lysate (35ug protein in RIPA buffer). Detected by chemiluminescence.Immunocytochemistry/Immunofluorescence: Acetylcholinesterase/ACHE Antibody [NB100-1519] - Immunofluorescence analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml), showing nuclear, membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Goat Polyclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

     1 Review

1 Publication
Recombinant Human HLA DRB4 GST (N-Term) Protein
H00003126-P01
12.5% SDS-PAGE Stained with Coomassie Blue.


Species Human
Applications WB, ELISA, PA

1 Publication
PMCH Antibody - BSA Free
NBP2-57697
Immunohistochemistry-Paraffin: PMCH Antibody [NBP2-57697] - Staining of human cerebral cortex, hypothalamus, liver and testis using Anti-PMCH antibody NBP2-57697 (A) shows similar protein distribution across tissues to independent antibody NBP2-13780 (B).Immunohistochemistry: PMCH Antibody [NBP2-57697] - Staining of mouse brain shows strong positivity in of neurons in the hypothalamus.

Rabbit Polyclonal
Species Human, Mouse
Applications IHC,  IHC-P

REM1 Antibody - Azide and BSA Free
H00028954-B01P
Western Blot: REM1 Antibody [H00028954-B01P] - Analysis of REM1 expression in transfected 293T cell line by REM1 polyclonal antibody. Lane 1: REM1 transfected lysate(32.78 KDa). Lane 2: Non-transfected lysate.Immunocytochemistry/Immunofluorescence: REM1 Antibody [H00028954-B01P] - Analysis of purified antibody to REM1 on HeLa cell. (antibody concentration 10 ug/ml)

Mouse Polyclonal
Species Human
Applications WB, ICC/IF

CHN 1 Antibody (OTI2G6) - Azide and BSA Free
NBP2-70411
Western Blot: CHN 1 Antibody (OTI2G6) - Azide and BSA Free [NBP2-70411] - Analysis of HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CHN 1.Immunocytochemistry/Immunofluorescence: CHN 1 Antibody (OTI2G6) - Azide and BSA Free [NBP2-70411] - Analysis of COS7 cells transiently transfected by pCMV6-ENTRY CHN 1.

Mouse Monoclonal
Species Human, Mouse, Rat
Applications WB, Flow, ICC/IF

Leptin/OB [HRP]
MOB00B
N/A Leptin/OB [HRP]N/A Leptin/OB [HRP]


Species Mouse, Rat
Applications ELISA

200 Publications
VGLUT1 Antibody - BSA Free
NBP3-13165
Western Blot: VGLUT1 Antibody [NBP3-13165] - Human tissue extract (30 ug) was separated by 7.5% SDS-PAGE, and the membrane was blotted with VGluT1 antibody diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to detect the primary antibody.Immunocytochemistry/Immunofluorescence: VGLUT1 Antibody [NBP3-13165] - VGLUT1 antibody detects VGLUT1 protein by immunofluorescent analysis. Sample: DIV10 rat E18 primary cortical neuron cells were fixed in 4% paraformaldehyde at RT for 15 min. Green: VGLUT1 stained by VGLUT1 antibody (NBP3-13165) diluted at 1:500. Red: Tau, stained by Tau antibody [GT287] diluted at 1:500. Blue: Fluoroshield with DAPI.

Rabbit Polyclonal
Species Human, Mouse, Rat
Applications WB, ICC/IF, IHC


Related Genes

Cataplexy And Narcolepsy has been researched against:

Related Pathways

Cataplexy And Narcolepsy has been linked to:

Related Diseases

Cataplexy And Narcolepsy has been studied in relation to diseases such as:

Related PTMs

Cataplexy And Narcolepsy has been studied in relation to posttranslational modifications (PTMs) including:

Alternate Names

Cataplexy And Narcolepsy is also known as Narcolepsy And Cataplexy, Narcolepsy With Cataplexy, Narcolepsy-cataplexy Syndrome, Syndrome, Narcolepsy-cataplexy.