ZFP36L1 Products

Description

TIS11B (tetradecanoyl phorbol acetate-inducible sequence 11b), also known as ZFP36L1, BRF1 (butyrate response factor 1), ERF1 (EGF response factor 1), cMG1, Berg36 or RNF162B, is a member of the tristetraprolin family. Tristetraprolin (TTP), or TIS11, is a zinc-binding protein encoded by the immediate-early response gene, Zfp-36. TIS11B, a relative of TTP, localizes to the nucleus and may function as a transcription factor involved in regulating the growth factor response. It is an evolutionarily conserved protein containing two C3H1-type zinc fingers and a repeating Cys-His motif. TIS11B is an mRNA binding protein and is known to interact with the 3'-untranslated region of VEGF mRNA, thereby decreasing its stability. This suggests that TIS11B is a potential target in antiangiogenic therapy. In addition, TIS11B may also be an important regulator of myogenesis, as its expression is upregulated during murine myoblast differentiation.

Bioinformatics

Entrez	677 Human 12192 Mouse
Uniprot	Q07352 Human
Product By Gene ID	677
Alternate Names	ZBRK1KRAB zinc finger protein ZFQR ZFQR Zinc finger and BRCA1-interacting protein with a KRAB domain 1 zinc finger protein 350 Zinc finger protein ZBRK1 zinc-finger protein ZBRK1

Research Areas for ZFP36L1

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Cell Biology
Signal Transduction