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Z-Val-Ala-Asp (OMe)-FMK Products


Description

Members of the caspase family play key roles in apoptosis and inflammation. Z-VAD(OMe)-FMK is a cell-permeable pan caspase peptide inhibitor that irreversibly binds to the catalytic site of caspases proteases, and inhibits caspasemediated apoptosis by preventing the processing of pro-caspases to their active forms (reviewed in 1-3). The ZVAD( OMe) peptide is O-methylated in the P1 position providing enhanced stability and increased cell permeability. Z-VAD(OMe)-FMK (Z-VAD-FMK) is typically used in assays to inhibit apoptosis. Z-VAD-FMK has been used in many different types of apoptosis assays and published extensively; for example, a PubMed search reveals over 1000 references citing Z-VAD-FMK between 1999 and 2003. Users may want to consult the literature for additional information regarding applications for Z-VAD-FMK.

Bioinformatics

Alternate Names
  • Z Val Ala Asp OMe FMK
  • Z-Val-Ala-Asp OMe-FMK