Wnt/RSPO3 Products

Description

Wnt signaling is known to promote self-renewal of adult stem cells. R-Spondins amplify Wnt signaling in adult stem cells by binding to LGR5 receptors resulting in increased levels of Wnt receptor localization at the membrane surface. Many current organoid protocols include addition of Wnt-3a and R-Spondin proteins to the media for optimal adult stem cell maintenance and health of organoids. Fusion proteins known known as Wnt Surrogates have been described that have enhanced solubility when compared to the widely used Wnt-3a protein and mirror the activities of Wnt signaling.¹ R&D Systems has constructed recombinant fusion proteins designed to bind elements of the Wnt receptor system including LGR-5, Frizzled, and LRP-5/6. These can initiate canonical Wnt signaling and are designed to simplify cell culture protocols by substituting for conditioned media or the addition of recombinant Wnt and R-Spondin.

Bioinformatics

Alternate Names

CRISTIN1 Protein with TSP type-1 repeat PWTSR roof plate-specific spondin-3 RSPO 3 R-spondin 3 homolog R-spondin-3 Thrombospondin type-1 domain-containing protein 2 THSD2 Wnt Wnt/RSPO3