VEGF165b Products

Description

Angiogenesis, required for all tumor growth, is stimulated by the expression of vascular endothelial growth factor (VEGF). VEGF is up-regulated in all known solid tumors but also in atherosclerosis, diabetic retinopathy, arthritis, and many other conditions. Conventional VEGF isoforms have been universally described as proangiogenic cytokines. VEGF 165b, an endogenous splice variant, is expressed as protein in normal cells and tissues and is circulating in human plasma. VEGF 165b binds VEGF receptor 2 with the same affinity as VEGF 165 but does not activate it or stimulate downstream signaling pathways. Moreover, it prevents VEGF 165-mediated VEGF receptor 2 phosphorylation and signaling in cultured cells. VEGF 165b is not angiogenic and it inhibits VEGF 165-mediated angiogenesis in rabbit cornea and rat mesentery.

Bioinformatics

Product By Gene ID	7422
Alternate Names	VEGF VPF VEGFA Vascular permeability factor VEGF-A VEGFMGC70609 VPFvascular endothelial growth factor MVCD1 vascular endothelial growth factor A

Diseases related to VEGF165b

Discover more about diseases related to VEGF165b.

Tumor Angiogenesis
Neoplasms
Pathologic Neovascularization
Malignant Neoplasms
Carcinoma
Neoplasm Metastasis
Age Related Macular Degeneration
Hypoxia
Choroidal Neovascularization
Retinal Diseases
Edema
Diabetic Retinopathy
Cell Invasion
Inflammation
Malignant Paraganglionic Neoplasm
Ischemia
Malignant Neoplasm Of Breast
Mammary Neoplasms
Adenocarcinoma

Pathways for VEGF165b

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Angiogenesis
Cell Proliferation
Secretion
Pathogenesis
Cell Growth
Tube Formation
Cell Migration
Endothelial Cell Proliferation
Localization
Cell Cycle
Wound Healing
Regeneration
Vasculogenesis
Cell Adhesion
Lymphangiogenesis
Endothelial Cell Migration
Reverse Transcription
Chemotaxis
Cell Death
Translation

Research Areas for VEGF165b

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Angiogenesis

PTMs for VEGF165b

Learn more about PTMs related to VEGF165b.

Phosphorylation
Cleavage
Glycosylation
Methylation
Reduction
Acetylation
Hydroxylation
Dephosphorylation
Ubiquitination
Oxidation
Biotinylation
Phosphorothioation
Demethylation
Sumoylation
Ribosylation
Myristoylation
Carboxylation
Prenylation
Iodination
Nitration

Bioinformatics Tool for VEGF165b

Discover related pathways, diseases and genes to VEGF165b. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.