Transcriptional regulator UME6 Products

Description

UME6 is a component of the RPD3C(L) histone deacetylase complex (HDAC) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. UME6 binds to the URS1 site (5'-AGCCGCCGA-3') and recruits the RPD3 histone deacetylase complex to the promoters to negatively regulate the expression of many genes including CAR1 (arginase), several required for sporulation, mating type switching, inositol metabolism, and oxidative carbon metabolism. Recruits also the ISW2 chromatin remodeling complex to promoters in a second gene repression pathway. UME6 also associates with the master regulator of meiosis IME1 in order to activate the expression of meiosis genes. It has both a positive and negative role in regulating phospholipid biosynthesis.

Bioinformatics

Alternate Names

CAR80 CARGR1 Negative transcriptional regulator of IME2 NIM2 Regulator of inducer of meiosis protein 16 RIM16 Unscheduled meiotic gene expression protein 6