TCR V beta 12 Products

Antibodies
TCR V beta 12 Antibody (S511) ...
TCR V beta 12 Antibody (S511)
NBP2-22495
Species: Hu
Applications: Flow, IHC, IP
Host: Mouse Monoclonal

Description

The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.

Bioinformatics

Entrez Mouse
Product By Gene ID 6957
Alternate Names
  • T cell receptor beta locus
  • T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster
  • T-cell receptor, beta cluster
  • TCRB
  • TRB

Research Areas for TCR V beta 12

Find related products by research area and learn more about each of the different research areas below.

Adaptive Immunity
Breast Cancer
Cancer
Cell Cycle and Replication
DNA Repair
Immunology