TCR V beta 12 Products

Description

The receptors on T cells consist of immunoglobulin like integral membrane glycoproteins containing 2 polypeptide subunits, alpha and beta, of similar molecular weight, 40 to 55 kD in the human. Like the immunoglobulins of the B cells, each T cell receptor subunit has, external to the cell membrane, an N terminal variable domain and a C terminal constant domain. T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex molecules at the surface of antigen presenting cells. Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci.

Bioinformatics

Entrez	21577 Mouse
Product By Gene ID	6957
Alternate Names	TCRB T-cell receptor, beta cluster TRB T-cell antigen receptor, beta polypeptide, T-cell receptor, beta cluster T cell receptor beta locus

Diseases related to TCR V beta 12

Discover more about diseases related to TCR V beta 12.

Precursor T-cell Lymphoblastic Leukemia-lymphoma
Acute Lymphocytic Leukemia
Chromosomal Translocation
Sclerosis
Polydactyly
Pleural Effusion Disorder
Multiple Sclerosis
Chromosome Inversion
Multiple Sclerosis, Relapsing-remitting
Leukemia
Chromosome Breakage
Lymphoma
Cytogenetic Abnormality

Pathways for TCR V beta 12

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Pathogenesis

Research Areas for TCR V beta 12

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Adaptive Immunity
Breast Cancer
Cancer
Cell Cycle and Replication
DNA Repair
Immunology

Bioinformatics Tool for TCR V beta 12

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