Description
Taxol (paclitaxel) is particularly effective as an anticancer agent because tubulin is not its only target. It also binds to a protein called Bcl-2, which normally blocks the process of apoptosis, or cell death. Taxol therefore plays a dual role in destroying dividing cells, firstly by stabilizing assembled microtubules and thereby halting mitosis, and secondly by inhibiting Bcl-2 and allowing apoptosis to proceed.
Bioinformatics
