Supervillin Products

Description

This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Two transcript variants encoding different isoforms of supervillin have been described.

Bioinformatics

Entrez	6840 Human
Uniprot	NP_003165 Human
Product By Gene ID	6840
Alternate Names	Archvillin DKFZp686A17191 membrane-associated F-actin binding protein p205 p205/p250 Supervillin SVIL