SPT3 Products

SPT3 Antibody
SPT3 Antibody
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SPT3 Antibody
SPT3 Antibody
Species: Hu, Mu, Rt, Po, Bv, Ca, Eq, Gt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
SPT3 Overexpression Lysate
SPT3 Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human SPT3 GST (N ...
Recombinant Human SPT3 GST (N-Term...
Species: Hu
Applications: WB, ELISA, PA, PAGE, AP
SPT3 Recombinant Protein Anti ...
SPT3 Recombinant Protein Antigen
Species: Hu
Applications: AC


The transcription of many RNA polymerase II-dependent genes requires Spt3, a member of the S. cerevisiae SAGA complex. Transcription from delta sequences, the long terminal repeats that flank yeast Ty elements, requires the yeast SPT3 gene. Spt3 and Spt20 work together to recruit TATA-box binding protein (TBP) to the core promoter allowing TBP to bind to SAGA-dependent promoters. Null mutations in the Spt3 gene cause defects in sporulation, diploid filamentous growth, and haploid invasive growth, indicating that Spt3 has an important role in both mating and development pathways in yeast. At the promoters of some genes including yeast HO, HIS3 and TRP3 genes, Spt3 inhibits binding of TBP, resulting in reduced transcription. This repressive effect of Spt3 can be overcome by another member of the SAGA complex, GCN5, which promotes the formation of a TBP/TFIIA complex by histone acetylation.


Entrez Human
Uniprot Human
Product By Gene ID 8464
Alternate Names
  • transcription initiation protein SPT3 homolog
  • SPT3-like protein
  • suppressor of Ty (S.cerevisiae) 3 homolog
  • suppressor of Ty 3 homolog (S. cerevisiae)

Diseases related to SPT3

Discover more about diseases related to SPT3.

Cell Transformation, Neoplastic
Hereditary Diseases
Growth Disorders
Dysequilibrium Syndrome

Pathways for SPT3

View related products by pathway and learn more about each of the pathways below.

Cell Proliferation
Cell Growth
Chromatin Remodeling

Research Areas for SPT3

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication

PTMs for SPT3

Learn more about PTMs related to SPT3.


Bioinformatics Tool for SPT3

Discover related pathways, diseases and genes to SPT3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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