SNX13 Products

Description

SNX13 encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delayes lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. [provided by RefSeq]

Bioinformatics

Entrez	23161 Human
Uniprot	AAH45667.1 Human NM_015132 Human NP_055947.1 Human
Product By Gene ID	23161
Alternate Names	KIAA0713RGS-PX1RGS domain- and PHOX domain-containing protein sorting nexin 13 sorting nexin-13