SNIP1 Products

Description

Members of the transforming growth factor-beta superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-beta family ligands are mediated by Smad proteins. A 396-amino acid nuclear protein termed SNIP1 was cloned and shown to harbor a nuclear localization signal (NLS) and a Forkhead-associated (FHA) domain. The carboxyl terminus of SNIP1 interacts with Smad1 and Smad2 in yeast two-hybrid as well as in mammalian overexpression systems. However, the amino terminus of SNIP1 harbors binding sites for both Smad4 and the coactivator CBP/p300. Overexpression of full-length SNIP1 or its amino terminus is sufficient to inhibit multiple gene responses to TGF-beta and CBP/p300, as well as the formation of a Smad4/p300 complex. Studies in Xenopus laevis further suggest that SNIP1 plays a role in regulating dorsomedial mesoderm formation by the TGF-beta family member nodal. Thus, SNIP1 is a nuclear inhibitor of CBP/p300 and its level of expression in specific cell types has important physiological consequences by setting a threshold for TGF-beta-induced transcriptional activation involving CBP/p300.

Bioinformatics

Entrez	79753 Human
Uniprot	AAH27040 Human NM_024700 Human NP_078976 Human NP_078976.2 Human Q8TAD8 Human
Product By Gene ID	79753
Alternate Names	dJ423B22.2 FHA domain-containing protein SNIP1 FLJ12553 RP3-423B22.3 Smad nuclear interacting protein (SNIP1) Smad nuclear interacting protein 1 smad nuclear-interacting protein 1