SNIP1 Products

Antibodies
SNIP1 Antibody
SNIP1 Antibody
NBP1-89428
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SNIP1 Antibody
SNIP1 Antibody
NBP2-20437
Species: Hu, Mu, Rt
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
SNIP1 Antibody
SNIP1 Antibody
H00079753-B01P
Species: Hu
Applications: WB, ELISA, ICC/IF
Host: Mouse Polyclonal
Antibody Pairs
SNIP1 Antibody Pair
SNIP1 Antibody Pair
H00079753-PW1
Species: Hu
Applications: WB, IP
Lysates
SNIP1 Overexpression Lysate ( ...
SNIP1 Overexpression Lysate (Denat...
H00079753-T01
Species: Hu
Applications: WB
SNIP1 Overexpression Lysate ( ...
SNIP1 Overexpression Lysate (Native)
NBL1-16281
Applications: WB
Proteins
SNIP1 Recombinant Protein Ant ...
SNIP1 Recombinant Protein Antigen
NBP1-89428PEP
Species: Hu
Applications: AC
SNIP1 Recombinant Protein
SNIP1 Recombinant Protein
NBP1-72317
Species: Hu
Applications: PAGE

Description

Members of the transforming growth factor-beta superfamily play critical roles in controlling cell growth and differentiation. Effects of TGF-beta family ligands are mediated by Smad proteins. A 396-amino acid nuclear protein termed SNIP1 was cloned and shown to harbor a nuclear localization signal (NLS) and a Forkhead-associated (FHA) domain. The carboxyl terminus of SNIP1 interacts with Smad1 and Smad2 in yeast two-hybrid as well as in mammalian overexpression systems. However, the amino terminus of SNIP1 harbors binding sites for both Smad4 and the coactivator CBP/p300. Overexpression of full-length SNIP1 or its amino terminus is sufficient to inhibit multiple gene responses to TGF-beta and CBP/p300, as well as the formation of a Smad4/p300 complex. Studies in Xenopus laevis further suggest that SNIP1 plays a role in regulating dorsomedial mesoderm formation by the TGF-beta family member nodal. Thus, SNIP1 is a nuclear inhibitor of CBP/p300 and its level of expression in specific cell types has important physiological consequences by setting a threshold for TGF-beta-induced transcriptional activation involving CBP/p300.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 79753
Alternate Names
  • RP3-423B22.3
  • smad nuclear-interacting protein 1
  • FLJ12553
  • Smad nuclear interacting protein (SNIP1)
  • FHA domain-containing protein SNIP1
  • dJ423B22.2
  • Smad nuclear interacting protein 1

Pathways for SNIP1

View related products by pathway and learn more about each of the pathways below.

Cell Proliferation
Cell Cycle
Rna Processing
Localization
Aging
G1 Phase
Cell Growth
Mesoderm Formation
Epithelial To Mesenchymal Transition

PTMs for SNIP1

Learn more about PTMs related to SNIP1.

Phosphorylation
Nitration
Ubiquitination

Bioinformatics Tool for SNIP1

Discover related pathways, diseases and genes to SNIP1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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